Results 31 to 40 of about 57,731 (238)

Scientific validation of anti-arthritic effect of Kashayams – A polyherbal formulation in collagen induced arthritic rats

Journal of Ayurveda and Integrative Medicine, 2021
Background: Toll-like receptor-4 (TLR-4) mediates activation of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) resulting in induction of proinflammatory genes such as that encoding tumor necrosis factor-α (TNF-α) and interleukin ...
Aswathy I. S., Santhi Krishnan, Jasmine Peter, Vidya Sabu, A. Helen   +4 more
doaj   +1 more source

Differential response of basal and tetrahydrobiopterin-stimulated activities of placental type III nitric oxide synthase to sodium dodecyl sulphate: relation to dimeric structure [PDF]

Molecular Human Reproduction, 1998
The major enzyme isoform that synthesizes nitric oxide (NO) in first trimester human placentae is endothelial or type III NO-synthase (NOS III) which exhibits high specific activity in the microsomal fraction. In the present study, we investigated the possible protective and enzyme-stabilizing role of tetrahydropterin (BH4).
M, Tóth, Z, Kukor, M, Sahin-Tóth
openaire   +2 more sources

From Genes to Surgery: How NOS3 Intron 4 Shapes Obesity Risk and Metabolic Outcomes

Proceedings
Introduction: Obesity is a multifactorial disease with high global prevalence and substantial metabolic–cardiovascular burden [...]
Jéssica B. Macêdo, Carine Royer, Dante M. T. Teixeira, Calliandra M. S. Silva, Rosana C. Benito, Evelyn M. Kogawa, Linconl A. O. Benito, Izabel C. R. Silva   +7 more
doaj   +1 more source

Differential effects in CGRPergic, nitrergic, and VIPergic myenteric innervation in diabetic rats supplemented with 2% L-glutamine

Anais da Academia Brasileira de Ciências, 2016
The objective of this study was to investigate the effects of 2% L-glutamine supplementation on myenteric innervation in the ileum of diabetic rats, grouped as follows: normoglycemic (N); normoglycemic supplemented with L-glutamine (NG); diabetic (D ...
RENATA V.F. PEREIRA, DAVID R. LINDEN, MARCÍLIO H. MIRANDA-NETO, JACQUELINE N. ZANONI   +3 more
doaj   +1 more source

The novel Mas agonist, CGEN-856S, attenuates isoproterenol-induced cardiac remodeling and myocardial infarction injury in rats. [PDF]

PLoS ONE, 2013
CGEN-856S is a novel Mas agonist. Herein, we examined the effects of this peptide on isoproterenol (ISO)-induced cardiac remodeling and myocardial infarction (MI) injury.
Sílvia Q Savergnini, Danielle Ianzer, Mariana B L Carvalho, Anderson J Ferreira, Gerluza A B Silva, Fúlvia D Marques, Antônio Augusto B Peluso, Merav Beiman, Gady Cojocaru, Yossi Cohen, Alvair P Almeida, Galit Rotman, Robson A S Santos   +12 more
doaj   +1 more source

Characterization of a constitutive type III nitric oxide synthase in human U937 monocytic cells: stimulation by soluble CD23

Immunology, 1997
The soluble cleavage fragment of the low‐affinity immunoglobulin E (IgE) receptor/CD23 (sCD23 25 000 MW) and antibodies directed against their receptors on monocytes, CD11b and CD11c, stimulate the production of nitric oxide (NO) by these cells and we have suggested that the enzyme involved could be related to the endothelial constitutive type III ...
V, Roman, N, Dugas, A, Abadie, C, Amirand, H, Zhao, B, Dugas, J P, Kolb   +6 more
openaire   +3 more sources

Inhibition or knock out of Inducible nitric oxide synthase result in resistance to bleomycin-induced lung injury

Respiratory Research, 2005
Background In the present study, by comparing the responses in wild-type mice (WT) and mice lacking (KO) the inducible (or type 2) nitric oxide synthase (iNOS), we investigated the role played by iNOS in the development of on the lung injury caused by ...
Crimi Nunzio, Gili Elisa, Frasca Giuseppina, Sortino Maria, Mazzon Emanuela, Failla Marco, Di Paola Rosanna, Cuzzocrea Salvatore, Genovese Tiziana, Caputi Achille P, Vancheri Carlo   +10 more
doaj   +1 more source

Emerging concepts about NAIP/NLRC4 inflammasomes

Frontiers in Immunology, 2014
NAIP/NLRC4 inflammasome complexes are activated in response to proteins from virulent bacteria that reach the cell cytosol. Specific NAIP proteins bind to the agonists and then physically associate with NLRC4 to form an inflammasome complex able to ...
Silvia Lucena Lage, Carla eLongo, Laura Migliari Branco, Thais Boccia da Costa, Carina de Lima Buzzo, Karina Ramalho Bortoluci   +5 more
doaj   +1 more source

The sorafenib anti-relapse effect after alloHSCT is associated with heightened alloreactivity and accumulation of CD8+PD-1+ (CD279+) lymphocytes in marrow. [PDF]

PLoS ONE, 2018
We studied three FLT3 ITD acute myeloid leukemia (AML) patients who relapsed after allogeneic haematopoietic stem cell transplantation (alloHSCT) and received multikinase inhibitor (MKI) sorafenib as part of salvage therapy.
Andrzej Lange, Emilia Jaskula, Janusz Lange, Grzegorz Dworacki, Dorota Nowak, Aleksandra Simiczyjew, Monika Mordak-Domagala, Mariola Sedzimirska   +7 more
doaj   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source