Results 31 to 40 of about 127,382 (281)

A novel long non-coding natural antisense RNA is a negative regulator of Nos1 gene expression [PDF]

, 2015
Long non-coding natural antisense transcripts (NATs) are widespread in eukaryotic species. Although recent studies indicate that long NATs are engaged in the regulation of gene expression, the precise functional roles of the vast majority of them are ...
AC Thénié, B Holmqvist, B Kuzin, B Moreno-Lopez, BL Sopher, C-H Cheng, D Dahary, DS Bredt, E Ciani, E Pavesi, GB Robb, J Chen, J Garthwaite, J-T Li, JB Kelley, JE Fish, JH Brann, K Matsui, KY Kwan, L Zhou, MA Faghihi, MA Packer, ME Evangelopoulos, ME Evangelopoulos, MHT Ling, N Peunova, P Ogilvie, RG Tremblay, S Hindley, S Korneev, SA Korneev, SA Korneev, SA Korneev, SA Korneev, SM Gibbs, SR Vincent, U Forstermann, V Calabrese, Y Zhang   +38 more
core   +1 more source

Multi-omic signatures of atherogenic dyslipidaemia: pre-clinical target identification and validation in humans

Journal of Translational Medicine, 2021
Background Dyslipidaemia is a major risk factor for atherosclerosis and cardiovascular diseases. The molecular mechanisms that translate dyslipidaemia into atherogenesis and reliable markers of its progression are yet to be fully elucidated.
Mariola Olkowicz, Izabela Czyzynska-Cichon, Natalia Szupryczynska, Renata B. Kostogrys, Zdzislaw Kochan, Janusz Debski, Michal Dadlez, Stefan Chlopicki, Ryszard T. Smolenski   +8 more
doaj   +1 more source

Pharmacology and clinical drug candidates in redox medicine [PDF]

, 2015
SIGNIFICANCE Oxidative stress is suggested to be a disease mechanism common to a wide range of disorders affecting human health. However, so far, the pharmacotherapeutic exploitation of this, for example, based on chemical scavenging of pro-oxidant ...
Casas, Ana I, Cuadrado, Antonio, Dao, V Thao-Vi, Di Lisa, Fabio, Ghezzi, Pietro, Jaquet, Vincent, Kaludercic, Nina, Maghzal, Ghassan J, Robledinos-Anton, Natalia, Schmidt, Harald H H W, Seredenina, Tamara, Stocker, Roland   +11 more
core   +3 more sources

Pro-atherosclerotic disturbed flow disrupts caveolin-1 expression, localization, and function via glycocalyx degradation

Journal of Translational Medicine, 2018
Background Endothelial-dependent atherosclerosis develops in a non-random pattern in regions of vessel bending and bifurcations, where blood flow exhibits disturbed flow (DF) patterns.
Ian C. Harding, Ronodeep Mitra, Solomon A. Mensah, Ira M. Herman, Eno E. Ebong   +4 more
doaj   +1 more source

Chimeras of Nitric-oxide Synthase Types I and III Establish Fundamental Correlates between Heme Reduction, Heme-NO Complex Formation, and Catalytic Activity [PDF]

Journal of Biological Chemistry, 2001
Neuronal nitric-oxide synthase (nNOS or NOS I) and endothelial NOS (eNOS or NOS III) differ widely in their reductase and nitric oxide (NO) synthesis activities, electron transfer rates, and propensities to form a heme-NO complex during catalysis.
S, Adak, K S, Aulak, D J, Stuehr
openaire   +2 more sources

Type III Secretion Protein, PcrV, Impairs Pseudomonas aeruginosa Biofilm Formation by Increasing M1 Macrophage-Mediated Anti-bacterial Activities

Frontiers in Microbiology, 2020
Pseudomonas aeruginosa biofilms employ a variety of strategies to hijack the host immune defense system to achieve chronic infection. However, the bacterial components that are involved in this process are not yet fully understood.
Hua Yu, Junzhi Xiong, Jing Qiu, Xiaomei He, Halei Sheng, Qian Dai, Defeng Li, Rong Xin, Lu Jiang, Qiaoqiao Li, Qian Chen, Jin Peng, Maolin Wang, Xiancai Rao, Kebin Zhang   +14 more
doaj   +1 more source

Nonylphenol and octylphenol differently affect cell redox balance by modulating the nitric oxide signaling [PDF]

, 2018
Nonylphenol (NP) and octylphenol (OP) are pervasive environmental contaminants belonging to the broader class of compounds known as alkylphenols, with potential human toxic effects.
Arese, Marzia, Magnifico, MARIA CHIARA, Popov, Milica, Sarti, Paolo, Saso, Luciano, Xhani, Marla   +5 more
core   +3 more sources

Localization of nitric oxide synthase type III in the internal thoracic and radial arteries and the great saphenous vein: A comparative immunohistochemical study [PDF]

The Journal of Thoracic and Cardiovascular Surgery, 2003
Endothelial nitric oxide synthase type III is the key enzyme of the nitric oxide production in the vessel wall. In this study the localization of endothelial nitric oxide synthase type III within the wall of the human internal thoracic and radial arteries and the great saphenous vein was investigated.Specimens were harvested from 23 patients undergoing
Gaudino, M., Toesca Di Castellazzo, Amelia, Maggiano, N., Pragliola, C., Possati, G.   +4 more
openaire   +3 more sources

Compensatory Feto-Placental Upregulation of the Nitric Oxide System during Fetal Growth Restriction [PDF]

, 2012
Background: Fetal Growth Restriction is often associated with a feto-placental vascular dysfunction conceivably involving endothelial cells. Our study aimed to verify this pathogenic role for feto-placental endothelial cells and, coincidentally ...
Begliuomini, Silvia, Boldrini, Antonio, Casarosa, Elena, Coceani, Flavio, Fink, Bruno, Genazzani, Andrea R., Ghirri, Paolo, Pisaneschi, Silvia, Ripoli, Andrea, Sanchez, Angel Matias, Simoncini, Tommaso, Strigini, Francesca A. L.   +11 more
core   +6 more sources

Scientific validation of anti-arthritic effect of Kashayams – A polyherbal formulation in collagen induced arthritic rats

Journal of Ayurveda and Integrative Medicine, 2021
Background: Toll-like receptor-4 (TLR-4) mediates activation of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) resulting in induction of proinflammatory genes such as that encoding tumor necrosis factor-α (TNF-α) and interleukin ...
Aswathy I. S., Santhi Krishnan, Jasmine Peter, Vidya Sabu, A. Helen   +4 more
doaj   +1 more source