Results 41 to 50 of about 10,767,649 (278)

Characterization of a constitutive type III nitric oxide synthase in human U937 monocytic cells: stimulation by soluble CD23

Immunology, 1997
The soluble cleavage fragment of the low‐affinity immunoglobulin E (IgE) receptor/CD23 (sCD23 25 000 MW) and antibodies directed against their receptors on monocytes, CD11b and CD11c, stimulate the production of nitric oxide (NO) by these cells and we have suggested that the enzyme involved could be related to the endothelial constitutive type III ...
V, Roman, N, Dugas, A, Abadie, C, Amirand, H, Zhao, B, Dugas, J P, Kolb   +6 more
openaire   +3 more sources

Differential response of basal and tetrahydrobiopterin-stimulated activities of placental type III nitric oxide synthase to sodium dodecyl sulphate: relation to dimeric structure [PDF]

Molecular Human Reproduction, 1998
The major enzyme isoform that synthesizes nitric oxide (NO) in first trimester human placentae is endothelial or type III NO-synthase (NOS III) which exhibits high specific activity in the microsomal fraction. In the present study, we investigated the possible protective and enzyme-stabilizing role of tetrahydropterin (BH4).
M, Tóth, Z, Kukor, M, Sahin-Tóth
openaire   +2 more sources

From Genes to Surgery: How NOS3 Intron 4 Shapes Obesity Risk and Metabolic Outcomes

Proceedings
Introduction: Obesity is a multifactorial disease with high global prevalence and substantial metabolic–cardiovascular burden [...]
Jéssica B. Macêdo, Carine Royer, Dante M. T. Teixeira, Calliandra M. S. Silva, Rosana C. Benito, Evelyn M. Kogawa, Linconl A. O. Benito, Izabel C. R. Silva   +7 more
doaj   +1 more source

Differential effects in CGRPergic, nitrergic, and VIPergic myenteric innervation in diabetic rats supplemented with 2% L-glutamine

Anais da Academia Brasileira de Ciências, 2016
The objective of this study was to investigate the effects of 2% L-glutamine supplementation on myenteric innervation in the ileum of diabetic rats, grouped as follows: normoglycemic (N); normoglycemic supplemented with L-glutamine (NG); diabetic (D ...
RENATA V.F. PEREIRA, DAVID R. LINDEN, MARCÍLIO H. MIRANDA-NETO, JACQUELINE N. ZANONI   +3 more
doaj   +1 more source

Scientific validation of anti-arthritic effect of Kashayams – A polyherbal formulation in collagen induced arthritic rats

Journal of Ayurveda and Integrative Medicine, 2021
Background: Toll-like receptor-4 (TLR-4) mediates activation of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) resulting in induction of proinflammatory genes such as that encoding tumor necrosis factor-α (TNF-α) and interleukin ...
Aswathy I. S., Santhi Krishnan, Jasmine Peter, Vidya Sabu, A. Helen   +4 more
doaj   +1 more source

Inhibition or knock out of Inducible nitric oxide synthase result in resistance to bleomycin-induced lung injury

Respiratory Research, 2005
Background In the present study, by comparing the responses in wild-type mice (WT) and mice lacking (KO) the inducible (or type 2) nitric oxide synthase (iNOS), we investigated the role played by iNOS in the development of on the lung injury caused by ...
Crimi Nunzio, Gili Elisa, Frasca Giuseppina, Sortino Maria, Mazzon Emanuela, Failla Marco, Di Paola Rosanna, Cuzzocrea Salvatore, Genovese Tiziana, Caputi Achille P, Vancheri Carlo   +10 more
doaj   +1 more source

The novel Mas agonist, CGEN-856S, attenuates isoproterenol-induced cardiac remodeling and myocardial infarction injury in rats. [PDF]

PLoS ONE, 2013
CGEN-856S is a novel Mas agonist. Herein, we examined the effects of this peptide on isoproterenol (ISO)-induced cardiac remodeling and myocardial infarction (MI) injury.
Sílvia Q Savergnini, Danielle Ianzer, Mariana B L Carvalho, Anderson J Ferreira, Gerluza A B Silva, Fúlvia D Marques, Antônio Augusto B Peluso, Merav Beiman, Gady Cojocaru, Yossi Cohen, Alvair P Almeida, Galit Rotman, Robson A S Santos   +12 more
doaj   +1 more source

Nitric oxide synthase in skeletal muscle fibres of patients with type 2 diabetes [PDF]

, 2012
Muscle-derived nitric oxide (NO) mediates fundamental physiological actions on skeletal muscle including glucose uptake into muscle cells. Recently, we have shown that the altered glucose metabolism in skeletal muscle of patients with type 2 diabetes ...
Karla Punkt, Volker Adams, Katharina Kandt, Matthias Blueher, Andreas Oberbach, Igor Buchwalow   +5 more
core  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Effects of nitric oxide synthase inhibitor - Nitro-L-Arginine Methyl Ester, on silica-inducated inflammatory reaction and apoptosis [PDF]

, 2006
BACKGROUND: Although nitric oxide is overproduced by macrophages and neutrophils after exposure to silica, its role in silica-induced inflammatory reaction and apoptosis needs further clarification.
He Wang, Wang, He, Leigh, James, Leigh James, James Leigh, Wang He   +5 more
core   +1 more source