Results 251 to 260 of about 100,569 (330)

Deficient eNOS Phosphorylation Is a Mechanism for Diabetic Vascular Dysfunction Contributing to Increased Stroke Size

open access: yesStroke, 2013
Qian Li   +11 more
semanticscholar   +1 more source

Hyperhomocysteinemia‐Driven Ischemic Stroke: Unraveling Molecular Mechanisms and Therapeutic Horizons

open access: yesFood Science &Nutrition, Volume 13, Issue 7, July 2025.
Neurotoxicity of Hcy. (A figure that best represents the scope of the paper.) Homocysteine can reduce the tightness of endothelial cell connections, increase vascular permeability, and damage the blood–brain barrier. Homocysteine activates various glutamate receptors on the surfaces of neurons and glial cells, triggering excitotoxicity, promoting the ...
Bin Li, Yushun Kou, Lingna Zhang, Lin Yi
wiley   +1 more source

Exploring Astragaloside IV in Ischemic Heart Disease: A Comprehensive Systematic Review and Meta‐Analysis of Preclinical Cardiotoxicity Models

open access: yesJournal of Biochemical and Molecular Toxicology, Volume 39, Issue 7, July 2025.
This systematic review and meta‐analysis evaluated the therapeutic efficacy of Astragaloside IV in ischemic heart disease, encompassing 18 preclinical studies. The findings demonstrated that As‐IV significantly reduced myocardial infarction size and apoptosis while improving cardiac function and angiogenesis through various mechanisms, along with ...
Alosh Greeny   +7 more
wiley   +1 more source

The renoprotective effects of tadalafil on ischemia-reperfusion injury during partial nephrectomy in an animal model. [PDF]

open access: yesBMC Nephrol
Lee EH   +9 more
europepmc   +1 more source

Glutamine Metabolism: Molecular Regulation, Biological Functions, and Diseases

open access: yesMedComm, Volume 6, Issue 7, July 2025.
Tumor cells adapt to nutrient‐poor environments by altering metabolism to acquire essential nutrients. They convert glutamine into glutamate and α‐ketoglutarate, supporting mTOR activation and sugar biosynthesis. Disruption of mTORC1 signaling is linked to disease, while glutamine and leucine activation promotes cell growth and inhibits autophagy ...
Mudasir A. Kumar   +10 more
wiley   +1 more source

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