Results 271 to 280 of about 100,569 (330)

Association of T‐786C eNOS gene polymorphism with increased susceptibility to acute chest syndrome in females with sickle cell disease

, 2003
Kanu Sharan, Saul Surrey, Samir K. Ballas, Meggin K. Borowski, Marcella Devoto, Wang Kai-fen, Eric Sandler, Michael A. Keller   +7 more
openalex   +1 more source

Pathogenesis of Melasma Explained

International Journal of Dermatology, Volume 64, Issue 7, Page 1201-1212, July 2025.
Pathophysiology of melasma. ABSTRACT This review provides an in‐depth analysis of the pathophysiology of melasma and highlights recent studies that elucidate its underlying mechanisms. Given the prevalence of melasma, a thorough understanding of its pathogenesis is critical for the development of effective treatment strategies.
Lara Ali, Firas Al Niaimi
wiley   +1 more source

HTLV-1 infection altered expression of CCR2, CXCR2, eNOS genes, and oxidative stress in aorta and heart of male mice. [PDF]

Physiol Rep
Niazmand S, Rezaee SAR, Gholizadeh Navashenaq J, Mohamadian Roshan N, Ghoryani M, Rafatpanah H, Mahmoudabady M, Baghcheghi Y, Paseban M, Hedayati-Moghadam M.   +9 more
europepmc   +1 more source

Altered endothelial mitochondrial Opa1‐related fusion in mouse accelerates age‐associated vascular and kidney damage

Physiological Reports, Volume 13, Issue 13, July 2025.
Mitochondria fusion protects endothelial cells in aging through a reduction in ROS production by NOX2 and through a reduction of the inhibitory effect of Cav‐1 on eNOS, thus allowing NO production and vascular relaxation. Abstract Cardiovascular diseases are the major cause of death worldwide, and their frequency increases with age in association with ...
Carlotta Turnaturi, Loïck L'Hoste, Coralyne Proux, Linda Grimaud, Emilie Vessieres, Antonio Zorzano, Anne Teissier, Pascal Reynier, Raffaella Sorrentino, Guy Lenaers, Laurent Loufrani, Daniel Henrion   +11 more
wiley   +1 more source

Defenestration of Liver Sinusoidal Endothelial Cells: The Trigger of Liver Fibrosis. [PDF]

Pharmaceuticals (Basel)
Zhou J, Wang J, Zhang L, Zhang C, Tian C.   +4 more
europepmc   +1 more source

Redirecting Intermediary Metabolism to Counteract Cyanide Poisoning

The FASEB Journal, Volume 39, Issue 12, 30 June 2025.
Cyanide is coined “the classic metabolic poison”; however, FDA‐approved cyanide chelators do not counteract cyanide's metabolic damage. Here, we review the mechanisms of cyanide toxicity, with a focus on intermediary metabolism. We present the theory that, within the innate plasticity of the metabolome, there may reside metabolic pathways that can ...
Vik S. Bebarta, Anjali K. Nath
wiley   +1 more source

Lupus nephritis serum induces changes in gene expression in human glomerular endothelial cells, which is modulated by L-sepiapterin: implications for redox-mediated endothelial dysfunction. [PDF]

Lupus Sci Med
Russell DA, Van Beusecum JP, Markiewicz M, Sanchez SM, Barth JL, Oates JC.   +5 more
europepmc   +1 more source

The Direct and Individual Transcriptional Function of the Human Homodimeric and Heterodimeric Basic Helix–Loop–Helix Transcription Factors E47 and Scleraxis

The FASEB Journal, Volume 39, Issue 12, 30 June 2025.
The isolated yeast model allowed visualization of the function of the heterodimeric SCX and E47 transcription factors (TFs) in the absence of other interacting proteins. The findings support the need for additional transcription factor binding sites (TFBS) and a permissive chromatin landscape for these TFs to exert a positive transcriptional effect ...
Karla Miranda López‐Delucio, Tania Dessire Sandoval‐Gurubel, Carina Becerril, Carlos Campero‐Basaldua, Alicia González, Ana Lilia Torres‐Machorro   +5 more
wiley   +1 more source

Effects of Hormone Replacement Treatment with Estrogen and Progestins on the Vascular Renin-Angiotensin System of Ovariectomized Rats. [PDF]

Int J Mol Sci
Menezes LA, Endlich PW, Lima DSS, Peluso AA, de Almeida SA, Borgo MV, Santos RAS, de Abreu GR.   +7 more
europepmc   +1 more source

A Novel Function of NaV Channel β3 Subunit in Endothelial Cell Alignment Through Autophagy Modulation

The FASEB Journal, Volume 39, Issue 11, 15 June 2025.
NaVβ3 expression is increased by laminar shear stress (LSS) through KLF4 induction (1). NaVβ3 is retained within the cell and interacts with mTOR protein and colocalizes partially with LAMP1 and LC3B, lysosome and autophagosome markers, respectively (2). Since SiRNA SCN3B induces the decrease of LC3B expression and cell alignment in response to LSS (3),
Léa Réthoré, Anne‐Laure Guihot, Linda Grimaud, Coralyne Proux, Benjamin Barré, François Guillonneau, Catherine Guette, Alice Boissard, Cécile Henry, Jérôme Cayon, Rodolphe Perrot, Daniel Henrion, Christian Legros, Claire Legendre   +13 more
wiley   +1 more source