Results 301 to 310 of about 100,569 (330)
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European Journal of Pharmacology, 2007
Endothelium-derived hyperpolarizing factor (EDHF), notably in the microcirculation, plays an important role in the regulation of vascular tone. The cellular events that mediate EDHF are critically dependent, in a vessel dependent manner, on small conductance calcium-activated potassium channels (SK) and intermediate conductance calcium-activated ...
Anthie Ellis +6 more
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Endothelium-derived hyperpolarizing factor (EDHF), notably in the microcirculation, plays an important role in the regulation of vascular tone. The cellular events that mediate EDHF are critically dependent, in a vessel dependent manner, on small conductance calcium-activated potassium channels (SK) and intermediate conductance calcium-activated ...
Anthie Ellis +6 more
openaire +3 more sources
Responses of cerebral arterioles to ADP: eNOS-dependent and eNOS-independent mechanisms
American Journal of Physiology-Heart and Circulatory Physiology, 2004ADP mediates platelet-induced relaxation of blood vessels and may function as an important intercellular signaling molecule in the brain. We used pharmacological and genetic approaches to examine mechanisms that mediate responses of cerebral arterioles to ADP, including the role of endothelial nitric oxide synthase (eNOS).
Cynthia M. Lynch +2 more
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Regulation of eNOS in Caveolae
2012Caveolae are a specialized subset of lipid domains that are prevalent on the plasma membrane of endothelial cells. They compartmentalize signal transduction molecules which regulate multiple endothelial functions including the production of nitric oxide (NO) by the caveolae resident enzyme endothelial NO synthase (eNOS).
Philip W. Shaul, Chieko Mineo
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Targeting eNOS for stroke protection
Trends in Neurosciences, 2004Nitric oxide (NO) generated by endothelial NO synthase (eNOS) plays a crucial role in vascular function and homeostasis. NO possesses vasodilatory, anti-inflammatory, antithrombotic and antiproliferative properties. Augmentation of NO production increases cerebral blood flow, which can lead to neuroprotection during brain ischaemia.
Matthias Endres +3 more
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Irisin improves endothelial function in obese mice through the AMPK-eNOS pathway.
American Journal of Physiology. Heart and Circulatory Physiology, 2015Irisin is a novel hormone secreted by myocytes. Lower levels of irisin are independently associated with endothelial dysfunction in obese subjects. The objective of this study was to explore whether irisin exerts a direct vascular protective effect on ...
Fang Han +4 more
semanticscholar +1 more source
eNOS phosphorylation in health and disease
Biochimie, 2010Endothelium plays a fundamental role in maintaining the vascular tone by releasing various biochemical factors that modulate the contractile and relaxatory behavior of the underlying vascular smooth muscle, regulation of inflammation, immunomodulation, platelet aggregation, and thrombosis.
Jamila H. Siamwala +2 more
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eNOS uncoupling in cardiovascular diseases--the role of oxidative stress and inflammation.
Current pharmaceutical design, 2014Many cardiovascular diseases and drug-induced complications are associated with - or even based on - an imbalance between the formation of reactive oxygen and nitrogen species (RONS) and antioxidant enzymes catalyzing the break-down of these harmful ...
S. Karbach +4 more
semanticscholar +1 more source
American Journal of Physiology. Endocrinology and Metabolism, 2014
Endurance exercise training increases cardiac energy metabolism through poorly understood mechanisms. Nitric oxide (NO) produced by endothelial NO synthase (eNOS) in cardiomyocytes contributes to cardiac adaptation.
R. Vettor +12 more
semanticscholar +1 more source
Endurance exercise training increases cardiac energy metabolism through poorly understood mechanisms. Nitric oxide (NO) produced by endothelial NO synthase (eNOS) in cardiomyocytes contributes to cardiac adaptation.
R. Vettor +12 more
semanticscholar +1 more source
Journal of Computational Physics, 1994
Essentially non-oscillatory (ENO) schemes, which have high order accuracy in regions where solutions are smooth and effectively capture shocks and discontinuities, have been developed for numerical solution of hyperbolic equations. These methods have traditionally been implemented using explicit Euler or explicit Runge-Kutta time marching schemes and ...
Vasilios I. Manousiouthakis +1 more
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Essentially non-oscillatory (ENO) schemes, which have high order accuracy in regions where solutions are smooth and effectively capture shocks and discontinuities, have been developed for numerical solution of hyperbolic equations. These methods have traditionally been implemented using explicit Euler or explicit Runge-Kutta time marching schemes and ...
Vasilios I. Manousiouthakis +1 more
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Sustained hypertension despite endothelial-specific eNOS rescue in eNOS-deficient mice
Biochemical and Biophysical Research Communications, 2015The aim of the study was to evaluate the possible contribution of non-endothelial eNOS to the regulation of blood pressure (BP). To accomplish this, a double transgenic strain expressing eNOS exclusively in the vascular endothelium (eNOS-Tg/KO) has been generated by endothelial-specific targeting of bovine eNOS in eNOS-deficient mice (eNOS-KO ...
Tatsiana Suvorava +7 more
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