Results 61 to 70 of about 100,569 (330)
Regulation of eNOS enzyme activity by posttranslational modification.
Current pharmaceutical design, 2014 The regulation of endothelial NO synthase (eNOS) employs multiple different cellular control mechanisms impinging on level and activity of the enzyme. This review aims at summarizing the current knowledge on the posttranslational modifications of eNOS ...
E. Heiss, V. Dirsch
semanticscholar +1 more source
Advanced Materials, EarlyView.A novel hydrogen bond re‐orientation (HyBRO) strategy enables three‐dimensional (3D) printing of vascular microchannel networks with high accuracy. By switching sacrificial material interactions with nonsolvents, HyBRO prevents swelling and deformation, enabling accurate hierarchical channels spanning a tenfold size range.
Zhencheng Liao +5 more
wiley +1 more source
Advanced Science, EarlyView.Irisin is a crucial plasma biomarker and promising therapeutic target that reflects disease severity, pulmonary vascular remodeling status and clinical outcome in patients with pulmonary arterial hypertension (PAH). As a novel protective factor, irisin is downregulated in PAH. By ubiquitination, irisin promotes Enolase 1 degradation and suppresses cell
Na Sun +15 more
wiley +1 more source
Advanced Science, EarlyView.This study develops enucleated MSC‐derived microvesicles (Mito@euMVs) to deliver functional mitochondria for optimizing wound repair. By efficiently encapsulating mitochondria, Mito@euMVs rejuvenate hyperglycemia‐induced senescent fibroblasts and HUVECs. Using PVA microneedle patches, the therapeutic efficacy of Mito@euMVs is validated in diabetic rats
Zixuan Dong +3 more
wiley +1 more source
Veterinární Medicína, 2008 The osteogenic growth peptide (OGP) regulates the differentiation of marrow mesenchymal stem cells derived from human and rodent cell lines into osteoblasts.
H.B. Zhu +7 more
doaj +1 more source
The effects of severe hypoxia on nitric oxide parameters in hypoxia-tolerant rodent: nannospalax nehringi [PDF]
Kafkas Universitesi Veteriner Fakültesi Dergisi, 2018 Blind mole rats (BMRs) are solitary rodents which are tolerant to severe hypoxia. The aim of this study is to reveal the changes in nitric oxide (NO) and nitric oxide enzymes (NOS), which are involved in many physiological and pathological processes ...
Barış YILDIZ +6 more
doaj +1 more source
Tetrahydrobiopterin and eNOS dimer/monomer ratio?a clue to eNOS uncoupling in diabetes? [PDF]
Cardiovascular Research, 2005 See article by Cai et al. [14] (pages 823–831) in this issue. Nitric oxide (NO) generated by the endothelial NO synthase (eNOS) critically determines vascular tone as well as vascular wall homeostasis [1]. Reduced NO bioavailability, which is associated with an increase in the formation of reactive oxygen species within the vascular wall, is the ...
Johann Bauersachs, Andreas Schäfer
openaire +2 more sources
Journal of Diabetes Research, 2014 Diabetic nephropathy (DN) is the leading cause of end-stage renal disease in many countries. The animal models that recapitulate human DN undoubtedly facilitate our understanding of this disease and promote the development of new diagnostic markers and ...
Takamune Takahashi, Raymond C. Harris
semanticscholar +1 more source
Advanced Science, EarlyView.This study highlights GRK2 is a central mediator in OSS‐induced endothelial dysfunction. OSS activates GPCRs in endothelial cells, leading to GRK2 phosphorylation and the activation of AP‐1. AP‐1 induces inflammation, while also promoting NR4A1 expression and anchoring LKB1 in the nucleus, which suppresses AMPK activity. This cascade causes endothelial
Li‐Da Wu +18 more
wiley +1 more source
Vascular Health and Risk Management, 2020 Dyana Sarvasti,1 Isabella Lalenoh,2 Emanoel Oepangat,2 Budhi Setianto Purwowiyoto,3 Anwar Santoso,3 Rochmad Romdoni4 1Department of Internal Medicine, Faculty of Medicine Widya Mandala Catholic University, Surabaya, Indonesia; 2Department of Cardiology ...
Sarvasti D +5 more
doaj