Results 151 to 160 of about 4,789 (198)

Purinergic signaling modulates endothelial-to-mesenchymal transition in human aortic valve endothelial cells. [PDF]

BBA Adv
Schmidt V, Weber A, Lichtenberg A, Schrader J, Martsch P, Barth M, Akhyari P.   +6 more
europepmc   +1 more source

Hyperglycaemia-induced molecular reprogramming of proximal tubular epithelial cells and its contribution to diabetic kidney disease progression-a narrative review. [PDF]

Front Cell Dev Biol
Gbaa T.
europepmc   +1 more source

Redefining drug discovery: AI-driven strategies for efficient cancer therapeutics. [PDF]

Front Oncol
De D, Chakraborty S, Banerjee S.
europepmc   +1 more source

Identification of biomarkers of Shenhailong formula in benign prostatic hyperplasia treatment: An observation study using network pharmacology and Mendelian randomization analysis. [PDF]

Medicine (Baltimore)
Pan J, Yu M, Zhang L, Yin J, Liu J, Zhang S, Zhang P, Fan Q, Liu J, Li X.   +9 more
europepmc   +1 more source

Kinetic mechanism of ENPP1 ATPase: Implications for aberrant calcification disorders and enzyme replacement therapy. [PDF]

J Biol Chem
Michalchik MM, Potchernikov T, Lester ER, Braddock DT, Cao W, De La Cruz EM.   +5 more
europepmc   +1 more source

ENPP1 In the Regulation of Mineralization and Beyond [PDF]

Trends in Biochemical Sciences, 2019
ENPP1 is well known for its role in regulating skeletal and soft tissue mineralization. It primarily exerts its function through the generation of pyrophosphate, a key inhibitor of hydroxyapatite formation. Several previous studies have suggested that ENPP1 also contributes to a range of human diseases including diabetes, cancer, cardiovascular disease,
Dongxing Zhu, Fiona Roberts, Colin Farquharson   +2 more
exaly   +6 more sources

Role of Somatomedin-B-Like Domains on ENPP1 Inhibition of Insulin Signaling

Biochimica Et Biophysica Acta - Molecular Cell Research, 2013
The exact mechanism by which ectonucleotide pyrophosphatase phosphodiesterase 1 (ENPP1) inhibits insulin signaling is not known. ENPP1 contains two somatomedin-B-like domains (i.e. SMB 1 and 2) involved in ENPP1 dimerization in animal cells.
Rosa Di Paola, Antonella Marucci, René Massimiliano Marsano   +2 more
exaly   +3 more sources

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Hepatic ENPP1 expression is induced in diabetic rabbits

Mammalian Genome, 2006
The ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) is an inhibitor of the insulin receptor. Variants of ENPP1 are associated with infantile arterial calcification, obesity, and insulin resistance. To study the functional relevance of this protein in vivo, we cloned rabbit ENPP1 and studied its regulation in experimentally induced diabetes ...
Philipp, Eller, Kathrin, Hochegger, Andreas, Wehinger, Ivan, Tancevski, Wilfried, Schgoer, Andreas, Ritsch, Josef R, Patsch   +6 more
openaire   +2 more sources

The K121Q polymorphism of ENPP1 and peripheral arterial disease

Heart and Vessels, 2008
The K121Q variant of the ectonucleotide pyrophosphatase/ phosphodiesterase 1 (ENPP1) gene is associated with obesity, insulin resistance, and early myocardial infarction. Therefore, we hypothesized that the K121Q polymorphism might also be associated with an increased risk for peripheral arterial disease.
Philipp, Eller, Wilfried, Schgoer, Thomas, Mueller, Ivan, Tancevski, Egon, Demetz, Kristina, Duwensee, Andreas, Ritsch, Meinhard, Haltmayer, Josef R, Patsch   +8 more
openaire   +2 more sources