Results 161 to 170 of about 4,789 (198)
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The Influence of ENPP1 Expression in Mucosal Tissues

The FASEB Journal, 2017
Previous work has established that extracellular adenosine signaling is protective in mucosal inflammation and promotes the resolution of ongoing inflammation. The sources of extracellular adenosine include enzymatic processing from nucleotides, such as ATP and AMP, which can be liberated from a variety of cell types, including leukocytes.
Valerie Curtis   +4 more
openaire   +1 more source

Mutations in ENPP1 are associated with 'idiopathic' infantile arterial calcification

Nature Genetics, 2003
Idiopathic infantile arterial calcification (IIAC; OMIM 208000) is characterized by calcification of the internal elastic lamina of muscular arteries and stenosis due to myointimal proliferation. We analyzed affected individuals from 11 unrelated kindreds and found that IIAC was associated with mutations that inactivated ecto-nucleotide pyrophosphatase/
Frank, Rutsch   +21 more
openaire   +2 more sources

Clinical presentation and burden of ENPP1 deficiency in adults

Archives de Pédiatrie
While the clinical consequences of severe ENPP1 deficiency leading to the rare disorders generalized arterial calcification of infancy (GACI) and autosomal recessive hypophosphatemic rickets type 2 (ARHR2) are well defined and understood, much less is known about how this evolves into adulthood and how moderate ENPP1 deficiency can first manifest in ...
openaire   +2 more sources

ENPP1 Is an Innate Immune Checkpoint of the Anticancer cGAMP–STING Pathway in Breast Cancer

Proceedings of the National Academy of Sciences of the United States of America, 2023
Songnan Wang   +2 more
exaly  

ENPP1’s Regulation of Extracellular cGAMP Is a Ubiquitous Mechanism of Attenuating STING Signaling

Proceedings of the National Academy of Sciences of the United States of America, 2022
Anthony F Cordova   +2 more
exaly  

HETEROCYCLIC INHIBITORS OF ENPP1

2021
BETTIGOLE SARAH   +6 more
openaire   +3 more sources

IMINO SULFANONE INHIBITORS OF ENPP1

2021
COGAN DEREK A   +5 more
openaire   +2 more sources

Missense mutations in ENPP1 result in osteoporosis in patients and is recapitulated in the ENPP1 loss of function murine model

Bone Abstracts, 2019
Demetrios Braddock   +5 more
openaire   +1 more source

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