Results 31 to 40 of about 4,789 (198)

Deficiency of the bone mineralization inhibitor NPP1 protects against obesity and diabetes [PDF]

, 2014
The emergence of bone as an endocrine regulator has prompted a re-evaluation of the role of bone mineralization factors in the development of metabolic disease.
Elspeth M. Milne, Ahmed, S Faisal, Zhu, Dongxing, Morton, Nicholas M, Millan, José Luis, MacRae, Vicky E, Mathieu Ferron, José Luis Millan, Dongxing Zhu, Nicholas M. Morton, Ferron, Mathieu, Farquharson, Colin, Karsenty, Gerard, Gerard Karsenty, Carmen Huesa, Vicky E. MacRae, Morton, Nicholas M., James D. Glover, Ahmed, S. Faisal, Glover, James D, Colin Farquharson, Huesa, Carmen, MacRae, Vicky E., S. Faisal Ahmed, Glover, James D., Milne, Elspeth M, Milne, Elspeth M., Farquharson, Colin; id_orcid   +27 more
core   +1 more source

Role of theENPP1K121Q Polymorphism in Glucose Homeostasis [PDF]

Diabetes, 2008
OBJECTIVE— To study the role of the ENPP1 Q121 variant on glucose homeostasis in whites from Italy.RESEARCH DESIGN AND METHODS— We conducted case-control studies in 764 adults (from two independent samples of 289 nonobese and 485 obese individuals) and 240 overweight/obese children undergoing oral glucose tolerance testing (OGTT).
R. BARATTA, P. ROSSETTI, S. PRUDENTE, F. BARBETTI, D. SUDANO, A. NIGRO, M. G. FARINA, F. PELLEGRINI, TRISCHITTA, VINCENZO, L. FRITTITTA   +9 more
openaire   +3 more sources

High expression of ENPP1 in high-grade serous ovarian carcinoma predicts poor prognosis and as a molecular therapy target.

PLoS ONE, 2021
Recent studies have shown that the expression of ENPP1 is related to differentiation, death, dissemination and chemosensitivity of tumor cells. So far, there is no research in ovarian carcinoma.
Hanzhi Wang, Feng Ye, Caiyun Zhou, Qi Cheng, Huaizeng Chen   +4 more
doaj   +1 more source

PROMIS scores for adults with ENPP1 Deficiency.

, 2022
PROMIS scores for adults with ENPP1 Deficiency.
Pedro Huertas (4891903), Christine O’Brien (8602185), Beth Leiro (13162611), Liz Molloy (13162614), Gus Khursigara (13162608), Catherine Nester (13162617)   +5 more
core   +1 more source

From Myricetin to the Discovery of Novel Natural Human ENPP1 Inhibitors: A Virtual Screening, Molecular Docking, Molecular Dynamics Simulation, and MM/GBSA Study

Molecules, 2022
It was recently revealed that naturally occurring myricetin can inhibit ectonucleotidase ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1), which, in turn, can treat ischemic cardiac injury.
Shaohan Song, Zhiyu Shao
doaj   +1 more source

The hepatic ectonucleotide pyrophosphatase/phosphodiesterase 1 gene mRNA abundance is reduced by insulin and induced by dexamethasone

Brazilian Journal of Medical and Biological Research, 2018
Hormones regulate hepatic gene expressions to maintain metabolic homeostasis. Ectonucleotide pyrophosphatase/phosphodiesterase 1 has been thought to interfere with insulin signaling.
Huiwen Ma, Ping Wang, Dan Jin, Ting Jia, Hong Mao, Jiandi Zhang, Shi Zhao   +6 more
doaj   +1 more source

Discovery of VH domains that allosterically inhibit ENPP1

Nature Chemical Biology, 2023
AbstractEctodomain phosphatase/phosphodiesterase-1 (ENPP1) is overexpressed on cancer cells and functions as an innate immune checkpoint by hydrolyzing extracellular cyclic guanosine monophosphate adenosine monophosphate (cGAMP). Biologic inhibitors have not yet been reported and could have substantial therapeutic advantages over current small ...
Paige E. Solomon, Colton J. Bracken, Jacqueline A. Carozza, Haoqing Wang, Elizabeth P. Young, Alon Wellner, Chang C. Liu, E. Alejandro Sweet-Cordero, Lingyin Li, James A. Wells   +9 more
openaire   +4 more sources

Case Report and Review of Literature: Autosomal Recessive Hypophosphatemic Rickets Type 2 Caused by a Pathogenic Variant in ENPP1 Gene

Frontiers in Endocrinology, 2022
Autosomal recessive hypophosphatemic rickets type 2 (ARHR2) is a rare form of hereditary rickets, which is characterized by defective bone mineralization and renal phosphate wasting due to a loss-of-function variant in the ectonucleotide pyrophosphatase ...
Yunsoo Choe, Choong Ho Shin, Young Ah Lee, Man Jin Kim, Yun Jeong Lee   +4 more
doaj   +1 more source

New Insights into the Role of ENPP1 in Insulin Resistance [PDF]

Journal of Metabonomics & Metabolites, 2012
New Insights into the Role of ENPP1 in Insulin Resistance Ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) is a transmembrane glycoprotein highly expressed in adipocytes and also found in other tissues involved in glucose and lipid metabolism, including liver, skeletal muscle and beta cell of the pancreas.
Wentong, Pan, Manisha, Chandalia, Nicola, Abate   +2 more
openaire   +2 more sources

Studies on the Inhibition of Ectonucleotide Pyrophosphatase/Phosphodiesterase 1 (ENPP1) by 2-(3,4-Dihydroxyphenyl)-7,8-dihydroxy-3-methoxychromen-4-one, a Flavonoid from Pistacia chinensis

Chemistry, 2023
Ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) regulates skeletal and soft tissue mineralization by hydrolyzing nucleotide triphosphates and cyclic nucleotides, and is involved in the modulation of immune system. In fact, ENPP1 degrades 2′,3′-
Abdur Rauf, Zuneera Akram, Muhammad Naveed, Najla AlMasoud, Taghrid S. Alomar, Muhammad Saleem, Abdul Waheed, Giovanni Ribaudo   +7 more
doaj   +1 more source