Results 11 to 20 of about 4,789 (198)

Role of ENPP1 on adipocyte maturation. [PDF]

PLoS ONE, 2007
It is recognized that the ability of adipose tissue to expand in response to energy excess, i.e. adipocyte maturation, is important in determining systemic abnormalities in glucose and lipid metabolism. Ectonucleotide pyrophosphatase phosphodiesterase 1 (
Jian Liang, Mingui Fu, Ester Ciociola, Manisha Chandalia, Nicola Abate   +4 more
doaj   +7 more sources

Transcriptional activation of ENPP1 by osterix in osteoblasts and osteocytes [PDF]

European Cells & Materials, 2018
Ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) is the main source of extracellular pyrophosphate. Along with tissue-nonspecific alkaline phosphatase (TNAP), ENPP1 plays an important role in balancing bone mineralisation.
MM Gao , QN Su, TZ Liang, JX Ma, MJ Stoddart, RG Richards, ZY Zhou, XN Zou   +7 more
doaj   +5 more sources

A novel small molecule Enpp1 inhibitor improves tumor control following radiation therapy by targeting stromal Enpp1 expression

Scientific Reports
The uniqueness in each person’s cancer cells and variation in immune infiltrates means that each tumor represents a unique problem, but therapeutic targets can be found among their shared features.
Jason R Baird, Alejandro F Alice, Roland Saito, Qingqing Chai, Minhua Han, Cindy Ng, Stephanie Han, Beth Fernandez, Sarah Ledoux, Johannes Grosse, Alan J Korman, Megan Potuznik, Venkatesh Rajamanickam, Brady Bernard, Marka R Crittenden, Michael J Gough   +15 more
doaj   +4 more sources

Supplementary Table S1: Clinical Trials of ENPP1 inhibitors from ENPP1 Immunobiology as a Therapeutic Target

, 2023
<p>Clinical Trials of ENPP1 inhibitors</p>
Fernando Lecanda, Rafael Martínez-Monge, Borja Ruiz-Fernández de Córdoba   +2 more
core   +3 more sources

ENPP1 ameliorates vascular calcification via inhibiting the osteogenic transformation of VSMCs and generating PPi

Open Medicine, 2023
This study aims to investigate the impact of ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) on vascular calcification in rats. The rationale behind studying ENPP1’s role in vascular calcification lies in its potential to modulate ...
Wu Xiujuan, Shen Shuijuan, Wu Jiaying, Wu Shaorui, Wang Shimi, Di Feng   +5 more
doaj   +2 more sources

Investigation of the role of ENPP1 and TNAP genes in chondrocalcinosis [PDF]

Rheumatology, 2006
Extracellular inorganic pyrophosphate (ePPi) inhibits certain forms of pathological mineralization while promoting others. Three molecules involved in ePPi regulation are important candidates for the development of calcium pyrophosphate dihydrate chondrocalcinosis (CPPD CC). These include ANKH, ectonucleotide pyrophosphatase (ENPP1) and TNAP.
Zhang, Y, Brown, M A, Peach, C, Russell, G, Wordsworth, B P   +4 more
openaire   +7 more sources

Inhibition of Vascular Smooth Muscle Cell Proliferation by ENPP1: The Role of CD73 and the Adenosine Signaling Axis

Cells
The Ectonucleotide Pyrophosphatase/Phosphodiesterase 1 (ENPP1) ectoenzyme regulates vascular intimal proliferation and mineralization of bone and soft tissues.
Boris Tchernychev, Yvonne Nitschke, Di Chu, Caitlin Sullivan, Lisa Flaman, Kevin O’Brien, Jennifer Howe, Zhiliang Cheng, David Thompson, Daniel Ortiz, Frank Rutsch, Yves Sabbagh   +11 more
doaj   +2 more sources

Altered bone development and an increase in FGF-23 expression in Enpp1(-/-) mice. [PDF]

PLoS ONE, 2012
Nucleotide pyrophosphatase phosphodiesterase 1 (NPP1) is required for the conversion of extracellular ATP into inorganic pyrophosphate (PP(i)), a recognised inhibitor of hydroxyapatite (HA) crystal formation.
Neil Charles Wallace Mackenzie, Dongxing Zhu, Elspeth M Milne, Rob van 't Hof, Aline Martin, Leigh Darryl Quarles, José Luis Millán, Colin Farquharson, Vicky Elisabeth MacRae   +8 more
doaj   +2 more sources

Investigating ANKH and ENPP1 in Slovakian families with chondrocalcinosis

Rheumatology International, 2011
Familial articular chondrocalcinosis (CC) was first reported in 1963. It is characterised by multiple calcifications of hyaline and fibrous cartilage in the joints and intervertebral discs. Mutations in ANKH have been identified in several pedigrees as a monogenic cause for this disorder.
Couto, Ana, Zhang, Yun, Timms, Andrew, Bruges-Armas, Jacome, Sequeiros, Jorge, Brown, Matthew   +5 more
openaire   +6 more sources

Metabolic consequences of ENPP1 overexpression in adipose tissue

American Journal of Physiology-Endocrinology and Metabolism, 2011
Ectonucleotide pyrophosphate phosphodiesterase (ENPP1) has been shown to negatively modulate insulin receptor and to induce cellular insulin resistance when overexpressed in various cell types. Systemic insulin resistance has also been observed when ENPP1 is overexpressed in multiple tissues of transgenic models and attributed largely to tissue insulin
Wentong, Pan, Ester, Ciociola, Manish, Saraf, Batbayar, Tumurbaatar, Demidmaa, Tuvdendorj, Sneha, Prasad, Manisha, Chandalia, Nicola, Abate   +7 more
openaire   +4 more sources