Results 1 to 10 of about 4,789 (198)

ENPP1, An Old Enzyme With New Functions, and Small Molecule Inhibitors—A STING in the Tale of ENPP1 [PDF]

Molecules, 2019
Ectonucleotide pyrophosphatase/phosphodiesterase I (ENPP1) was identified several decades ago as a type II transmembrane glycoprotein with nucleotide pyrophosphatase and phosphodiesterase enzymatic activities, critical for purinergic signaling. Recently,
Kenneth I Onyedibe, Herman O. Sintim, Modi Wang   +2 more
exaly   +6 more sources

JUN–ENPP1–cGAS–STING axis mediates immune evasion and tumor progression in bladder cancer [PDF]

Journal of Translational Medicine
Background Ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) regulates extracellular nucleotide metabolism and immune suppression. While ENPP1 is implicated in tumor progression and immune evasion in various cancers, its role in bladder cancer ...
Chengyu You, Qixiang Fang, Liangliang Qing, Xi Xiao, Yang Liu, Weiguang Yang, Qingchao Li, Rongxin Li, Yanan Wang, Zhilong Dong   +9 more
doaj   +3 more sources

Tumor Exosomal ENPP1 Hydrolyzes cGAMP to Inhibit cGAS-STING Signaling

Advanced Science
To evade immune surveillance, tumor cells express ectonucleotide pyrophosphatase phosphodiesterase 1 (ENPP1) on the surface of their membrane, which degrades extracellular cyclic GMP‐AMP (cGAMP), thereby inhibiting the cyclic GMP‐AMP synthase (cGAS ...
Chaoyong Yang, Zhu Jinchao, Jianzhou Feng   +2 more
exaly   +3 more sources

Human Antibodies Targeting ENPP1 as Candidate Therapeutics for Cancers

Frontiers in Immunology, 2023
Ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) is a type II transmembrane glycoprotein expressed in many tissues. High expression levels of ENPP1 have been observed in many cancer types such as lung cancer, ovarian cancer, and breast cancer ...
Poul H Sorensen, Gregg B Morin, Dimiter S Dimitrov   +2 more
exaly   +3 more sources

Prenatal Presentation of ENPP1-Associated Generalized Arterial Calcification of Infancy at 15 + 1 Weeks: A Fetal Phenotype-Genotype Report. [PDF]

Prenat Diagn
Prenatal Diagnosis, Volume 46, Issue 10, Page 1676-1679, September 2026.
Tekesin I, Kerst G, Chiaie LD, Dinwiddie A, Gabriel H.   +4 more
europepmc   +2 more sources

Targeting the DNA Damage Response in Cancer. [PDF]

MedComm (2020)
Targeting the DNA damage response (DDR) reshapes both tumor vulnerability and antitumor immunity. DNA lesions and DDR inhibitors can promote cytosolic nucleic‐acid sensing, antigen presentation, and immune activation, but can also induce adaptive immune escape.
Qiao Y, Kang B, Zhang J, Zhang R, Li J.
europepmc   +2 more sources

TNAP and PHOSPHO1 Function Synergistically to Afford Critical Control Over the Mineralization of the Postnatal Murine Skeleton. [PDF]

Adv Sci (Weinh)
Biomineralization underpins skeletal development, yet its molecular control remains incompletely understood. Using a novel murine knockout model, this study reveals the essential and complementary roles of PHOSPHO1 and TNAP in postnatal skeletal development.
Bourne LE, Sharma A, Dillon S, Keen J, Jayash SN, Crump N, Evans LAE, Karmali M, Promruk W, Clarkin CE, Narisawa S, Stephen L, Foster BL, Millán JL, Farquharson C, Staines KA.   +15 more
europepmc   +2 more sources

ENPP1 and IFIT2 in PBMCs as early predictive biomarkers for HBsAg clearance and responses to Peg-IFN-α in HBeAg-negative chronic hepatitis B patients [PDF]

Frontiers in Immunology
ObjectiveTo investigate whether early on-treatment expression of ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) and interferon-induced protein with tetratricopeptide repeats 2 (IFIT2) in peripheral blood mononuclear cells (PBMCs) could serve ...
Hao Pang, Xinglin Fu, Jinhong Jiang, Bo Qin   +3 more
doaj   +2 more sources

ENPP1 inhibitor with ultralong drug-target residence time as an innate immune checkpoint blockade cancer therapy [PDF]

Cell Reports Medicine
Summary: Only one in five patients respond to immune checkpoint inhibitors, which primarily target adaptive immunity. Ectonucleotide pyrophosphatase/phophodiesterase 1 (ENPP1), the dominant hydrolase of 2′3′-cyclic-GMP-AMP (cGAMP) that suppresses ...
Songnan Wang, Randolph M. Johnson, Jacqueline A. Carozza, Daniel Fernandez, Jan Scicinski, Neil A. Verity, Rachel Mardjuki, Xujun Cao, Yingjie Guo, Jacqueline Papkoff, Nigel Ray, Lingyin Li   +11 more
doaj   +2 more sources

Enpp1 deficiency caused chondrocyte apoptosis by inhibiting AMPK signaling pathway

Journal of Orthopaedic Surgery and Research, 2023
Objective and background The deficiency of ectonucleotide pyrophosphatase/phosphodiesterase 1 (Enpp1) causes the phenotype similar to knee osteoarthritis (OA). However, the molecular mechanism is poorly understood.
Zhiqiang Gao, Qiang Wang, Kai Guo, Xinhua Li, Yufeng Huang   +4 more
doaj   +1 more source