Results 171 to 180 of about 996,291 (283)

Loss of Stat3 in Prx1+ Progenitors Impairs Molar Root Development

open access: yesAdvanced Biology, EarlyView.
Stat3 critically regulates mandibular first molar and alveolar bone morphogenesis. Conditional ablation of Stat3 disrupts the osteogenic capacity of Prx1+ mesenchymal progenitors, as evidenced across in vivo and in vitro models. Abstract Signal Transducer and Activator of Transcription 3 (Stat3) acts as a central transcriptional modulator coordinating ...
Xin Feng   +10 more
wiley   +1 more source

A Spatially Resolved View on the Aging Substantia nigra: An Exploratory Proteomic Study

open access: yesAdvanced Biology, EarlyView.
Although aging is the most important risk factor for several neurodegenerative diseases, the molecular effects of physiological aging are still understudied. By applying spatially‐resolved proteomic analyses of the human substantia nigra pars compacta, alterations in vesicular trafficking and mitochondrial proteins are observed, as well as reduced ...
Britta Eggers   +10 more
wiley   +1 more source

Generational effects in Down syndrome: Enriched environment enhances functionality without reducing Alzheimer's disease risk. [PDF]

open access: yesAlzheimers Dement
Vaqué-Alcázar L   +17 more
europepmc   +1 more source

Alteration of Synaptic Activity–Regulating Genes Underlying Functional Improvement by Long-term Exposure to an Enriched Environment in the Adult Brain

open access: green, 2013
Min Young Lee   +7 more
openalex   +2 more sources

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