Results 91 to 100 of about 880,441 (304)
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Natural Gas Industry BThe Weixinan Depression is a petroliferous depression in the Beibu Gulf Basin. After years of related research, scholars have gained a certain understanding of the oil accumulation law in the depression.
Jiajun Qu +5 more
doaj +1 more source
The heavy ion compositional signature in 3He-rich solar particle events [PDF]
A survey of the approx. 1 MeV/nucleon heavy ion abundances in 66 He3-rich solar particle events was performed using the Max-Planck-Institut/University of Maryland and Goddard Space Flight Center instruments on the ISEE-3 spacecraft. The observations were
Hovestadt, D. +4 more
core +1 more source
Targeting and regulatory mechanisms in chromosome-wide gene regulation using Drosophila melanogaster as a model organism [PDF]
, 2010 Tese de mestrado. Biologia (Biologia Molecular e Genética). Universidade de Lisboa, Faculdade de Ciências, 2010O cromossoma 4 de Drosophila melanogaster é muito heterocromático, sendo rico em DNA satélite e DNA de elementos transposáveis. Apesar das suas
Figueiredo, Ana Margarida Adónis, 1986-
core
FEBS Letters, EarlyView.Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas +3 more
wiley +1 more source
Turn-off of Deuterium Astration in the Recent Star Formation of the Galaxy Disk
, 2010 Chemical features of the local stellar disk have firmly established that long-term, continuous star formation has been accompanied by a steady rate of accretion of low-metallicity gas from the halo.
Tsujimoto, T.
core +1 more source
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
Metallicity of the Massive Protoplanets Around HR 8799 If Formed by Gravitational Instability
, 2009 The final composition of giant planets formed as a result of gravitational instability in the disk gas depends on their ability to capture solid material (planetesimals) during their 'pre-collapse' stage, when they are extended and cold, and contracting ...
Alexander +35 more
core +1 more source