Results 131 to 140 of about 880,441 (304)

Enrichment Mechanism of Rare Earth Elements in the Aluminum-bearing Rock Series of the Jinsha Area in Northwest Guizhou Province

Kuangchan zonghe liyong
The rare earth element (REE) content in the aluminum-bearing rock series of the Lower Carboniferous Jiujialu Formation in the Jinsha Area of northwest Guizhou is relatively high, showing certain exploration potential.
Kun QIE, Yang LAI, Daxing GONG, Enyuan TIAN   +3 more
doaj   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Mineralogy and geochemistry of shale from Shanxi Formation, Southern North China Basin: Implication for organic matter accumulation

Unconventional Resources
The Permian Taiyuan and Shanxi coal-bearing formations are recognized as the primary source rocks and promising shale gas reservoirs in North China.
Qian Chen, Pei Li, Xiaoliang Wei, Changsheng Chen, Wei Dang, Haikuan Nie, Jinchuan Zhang   +6 more
doaj   +1 more source

Reconstructing the Climatic-Oceanic Environment and Exploring the Enrichment Mechanism of Organic Matter in the Black Shale across the Late Ordovician-Early Silurian Transition on the Upper Yangtze Platform Using Geochemical Proxies. [PDF]

ACS Omega, 2020
Wei Z, Wang Y, Wang G, Zhang T, He W, Ma X.   +5 more
europepmc   +1 more source

Editorial: Environmental Enrichment as a Treatment? Epigenetic Mechanisms, Challenges and Limitations [PDF]

Frontiers in Pharmacology, 2021
Redolat R., Mesa-Gresa P., Sampedro-Piquero P., Cutuli D.   +3 more
openaire   +5 more sources

Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity

Molecular Oncology, EarlyView.
Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek, Jenny Sprooten, Abhishek D. Garg   +2 more
wiley   +1 more source

Enrichment Geological Conditions and Resource Evaluation Methods for the Gas in Thinly Interbedded Coal Measures: A Case Study of the Chengzihe Formation in the Jixi Basin

Energies
The Cretaceous Chengzihe Formation in the Jixi Basin hosts abundant coal measure gas resources. Analyzing the geological conditions for gas enrichment and evaluating its resource potential are essential for advancing unconventional gas exploration ...
Jiangpeng Guo, Shu Tao, Caiqin Bi, Yi Cui, Bin Yu, Yijie Wen   +5 more
doaj   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Sulfur cycling processes and its effect on arsenic mobility in groundwater from typical areas of the Beijing Plain

Shuiwen dizhi gongcheng dizhi
The widespread occurrence of naturally high-arsenic (As) groundwater in Beijing severely restricts the utilization of regional groundwater resources.
Rui BAO, Zhipeng GAO, Huaming GUO, Zheng DING, Chunping JIANG, Yao LI, Shiping XING, Yutong WANG   +7 more
doaj   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source