Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
Oil and natural gas geochemistry in offshore China: Advances and challenges
Natural Gas Industry BFor many years, oil and natural gas geochemistry has been key to hydrocarbon exploration and exploitation in offshore China. Onshore oil fields have been thoroughly explored and exploited and have now entered the later stages of development. However, the
Dujie Hou +12 more
doaj +1 more source
Enrichment of tight oil and its controlling factors in central and western China
Petroleum Exploration and Development, 2021 Taking the tight oil of the Zhongnan sag in the Ordos Basin, Jimusar sag in the Junggar Basin and Qingxi sag in the Jiuquan Basin as study objects, based on field survey, dissection of tight oil reservoirs, sample test, modeling experiment and ...
Yan SONG +4 more
doaj +1 more source
IMF isotopic properties in semi-peripheral collisions at Fermi energies
, 2005 We study the neutron and proton dynamical behavior along the fragmentation path in semi-peripheral collisions: 58Fe+58Fe (charge asymmetric, N/Z = 1.23) and 58Ni+58Ni (charge symmetric, N/Z = 1.07), at 47 AMeV.
Baran +38 more
core +1 more source
On Lithium-6 as diagnostic of the lithium-enrichment mechanism in red giants
, 2020 High lithium-7 ($\mathrm{^7Li}$) abundances in giants are indicative of non-standard physical processes affecting the star. Mechanisms that could produce this signature include contamination from an external source, such as planets, or internal ...
Aguilera-Gómez, Claudia +2 more
core +1 more source
JUN dependency in distinct early and late BRAF inhibition adaptation states of melanoma. [PDF]
, 2016 A prominent mechanism of acquired resistance to BRAF inhibitors in BRAF (V600) -mutant melanoma is associated with the upregulation of receptor tyrosine kinases.
Atefi, Mohammad +16 more
core +3 more sources
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Low Thermal Conductivity Cement Slurry for Geothermal Well Cementing
Zuanjingye yu wanjingyeIn geothermal energy development, the heat loss of cement sheath plays a key role in affecting heat extraction efficiency. In this study, using class G cement as the base slurry, and hollow glass microspheres and modified palygorskite fiber as composite ...
Donghong DANG +5 more
doaj +1 more source
Sexual hormones in Achyla. V. Properties of hormone A of Achyla bisexualis [PDF]
, 1942 1. The hormonal coordinating mechanism of the sexual process in Achlya is briefly reviewed. 2. A technique is described for culturing the female plant of Achlya bisexualis in sufficient quantity to furnish material for the chemical study of hormone A ...
Haagen-Smit, A. J., Raper, John R.
core
PDE6δ-mediated sorting of INPP5E into the cilium is determined by cargo-carrier affinity [PDF]
, 2016 The phosphodiesterase 6 delta subunit (PDE6δ) shuttles several farnesylated cargos between membranes. The cargo sorting mechanism between cilia and other compartments is not understood.
Fansa, Eyad Kalawy +4 more
core +1 more source