Results 161 to 170 of about 30,637 (189)
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Pharmacokinetic evaluation of enrofloxacin in chickens
British Poultry Science, 19971. The pharmacokinetics and bioavailability of enrofloxacin in chickens were investigated following intravenous, intramuscular, subcutaneous and oral administration of 10 mg/kg body weight. A rapid distribution phase was followed by a slower elimination phase. 2. The apparent volume of distribution was 2.2 l/kg.
M I, Abd el-Aziz +3 more
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Nonlinear toxicokinetics of enrofloxacin in rats
Archives of Pharmacal Research, 2010The dose-dependent toxicokinetics of enrofloxacin were studied by administering various single subcutaneous doses (5, 10, 20, 40, 70, 100, 150, 200, 300 and 400 mg/kg) in male Sprague-Dawley rats. The blood samples were collected from the tail veins, and the plasma concentration of enrofloxacin was determined by an HPLC-fluorescence detection (FLD ...
Hee, Yi +9 more
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Anti-enrofloxacin antibody production by using enrofloxacin-screened HSA as an immunogen
Journal of Ocean University of China, 2005A two-step zero-length cross-linking procedure using active esters was successfully adopted for conjugating enrofloxacin (EF) to human serum albumin (HSA). The derived conjugate was characterized by UV spectrum and then used for immunization of BALB/C mice.
Chune Liu +3 more
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Pharmacokinetics of enrofloxacin in neonatal kittens
American Journal of Veterinary Research, 2004AbstractObjective—To determine the pharmacokinetics of enrofloxacin in neonatal kittens and compare the pharmacokinetics of enrofloxacin in young and adult cats.Animals—7 adult cats and 111 kittens (2 to 8 weeks old).Procedure—A single dose of 5 mg of enrofloxacin/kg was administered to adults (IV) and kittens (IV, SC, or PO).
M Alexis, Seguin +4 more
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Pharmacokinetic properties of enrofloxacin in rabbits
American Journal of Veterinary Research, 1991SUMMARY The pharmacokinetic properties of the fluoroquinolone antimicrobial enrofloxacina were studied in New Zealand White rabbits. Four rabbits were each given enrofloxacin as a single 5 mg/kg of body weight dosage by iv, sc, and oral routes over 4 weeks. Serum antimicrobial concentrations were determined for 24 hours after dosing.
R L, Broome +4 more
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Veterinary Research Communications, 2001
The pharmacokinetics of enrofloxacin and its active metabolite ciprofloxacin were investigated in goats after a single intramuscular administration of enrofloxacin at 2.5 mg/kg body weight. The plasma concentrations of enrofloxacin and ciprofloxacin were determined simultaneously by a HPLC method.
G S, Rao +5 more
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The pharmacokinetics of enrofloxacin and its active metabolite ciprofloxacin were investigated in goats after a single intramuscular administration of enrofloxacin at 2.5 mg/kg body weight. The plasma concentrations of enrofloxacin and ciprofloxacin were determined simultaneously by a HPLC method.
G S, Rao +5 more
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Journal of Veterinary Pharmacology and Therapeutics, 1995
Enrofloxacin, a quinolone antibiotic developed exclusively for use in animals, was investigated for its effects on the steady‐state pharmacokinetics of theophylline in six healthy Beagle dogs. A sustained‐release theophylline formulation was given alone (20 mg/kg per os twice daily at 12 h intervals) for 9 days and then co‐administered with ...
INTORRE, LUIGI +4 more
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Enrofloxacin, a quinolone antibiotic developed exclusively for use in animals, was investigated for its effects on the steady‐state pharmacokinetics of theophylline in six healthy Beagle dogs. A sustained‐release theophylline formulation was given alone (20 mg/kg per os twice daily at 12 h intervals) for 9 days and then co‐administered with ...
INTORRE, LUIGI +4 more
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Small Ruminant Research, 2002
Abstract Pharmacokinetic properties of the antimicrobial fluoroquinolone, enrofloxacin, were studied in female goats. Enrofloxacin was given to goats in a single dose of 2.5 mg kg −1 body weight by intravenous (i.v.) route. Blood samples were collected via jugular venipuncture into heparinized tubes at predetermined times after drug administration ...
G.S. Rao +5 more
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Abstract Pharmacokinetic properties of the antimicrobial fluoroquinolone, enrofloxacin, were studied in female goats. Enrofloxacin was given to goats in a single dose of 2.5 mg kg −1 body weight by intravenous (i.v.) route. Blood samples were collected via jugular venipuncture into heparinized tubes at predetermined times after drug administration ...
G.S. Rao +5 more
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Enrofloxacin Permeation Pathways across the Porin OmpC
The Journal of Physical Chemistry B, 2018In Gram-negative bacteria, the lack or quenching of antibiotic translocation across the outer membrane is one of the main factors for acquiring antibiotic resistance. An atomic-level comprehension of the key features governing the transport of drugs by outer-membrane protein channels would be very helpful in developing the next generation of ...
Prajapati +4 more
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Enrofloxacin inclusion complexes with cyclodextrins
Journal of Inclusion Phenomena and Macrocyclic Chemistry, 2011Inclusion complexes using α-, β-, γ-, and hydroxypropyl-β-CD (HP-β-CD) were produced with the antibiotic enrofloxacin, with the aim of increasing its solubility by complexation. Phase solubility diagrams were obtained, to confirm the formation of inclusion complexes, and to determine the solubility enhancement and stability constant of each complex ...
Luiza P. V. Calsavara +2 more
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