Results 51 to 60 of about 2,311 (133)

Harnessing controlled human infection models to accelerate vaccine development for neglected tropical diseases: Lessons from leishmaniasis

European Journal of Clinical Investigation, Volume 56, Issue 1, January 2026.
Controlled Human Infection Models (CHIMs) offer a powerful approach to accelerate vaccine development for neglected tropical diseases (NTDs). This review highlights scientific and translational advances enabled by CHIMs, with a focus on a novel Leishmania major model.
Vivak Parkash
wiley   +1 more source

Ensaio clínico com um novo anti-epiléptico (barbexaclone)

Arquivos de Neuro-Psiquiatria, 1977
Foi experimentado um novo anti-epiléptico (barbexaclone) em 48 pacientes que apresentavam 67 tipos de crises, destacando-se o fato de que todos eram casos considerados maus, seja pela intensidade das manifestações epilépticas, seja para refratariedade a ...
José Hermínio Bragatti, Gerda Horn Caleffi, Flávio José Prenna   +2 more
doaj   +1 more source

Model‐based evaluation of the interaction between ritonavir‐boosted atazanavir and rifampicin in Ugandan adults with HIV

British Journal of Clinical Pharmacology, Volume 91, Issue 12, Page 3471-3481, December 2025.
Aim Concomitant treatment of tuberculosis (TB) and human immunodeficiency virus (HIV) is complicated by drug‐drug interactions (DDI). This analysis aimed to characterize the DDI between ritonavir‐boosted atazanavir (ATV/r) and rifampicin in plasma and peripheral blood mononuclear cells (PBMC).
Allan Kengo, Juan Eduardo Resendiz‐Galvan, Letisha Najjemba, Henry Mugerwa, Amedeo De Nicolò, Antonio D'Avolio, Shakir Atoyebi, Lubbe Wiesner, Elin M. Svensson, Catriona Waitt, Paolo Denti   +10 more
wiley   +1 more source

Representações sociais de crianças participantes de um ensaio clínico sobre o pesquisador: de detentor do saber à criança curiosa

Saúde e Sociedade, 2014
Intervenções educativas constituem importantes ferramentas para a ampliação do conhecimento científico e em ensaios clínicos devem contribuir para a tomada de decisão quanto à participação na pesquisa.
Maria Flávia Carvalho Gazzinelli, Vânia de Souza, Fernanda Bicalho Pereira, Lucas Henrique Lobato de Araujo, Marconi Moura Fernandes, Patrícia Fernanda de Melo, Relbson de Matos Costa   +6 more
doaj   +1 more source

New Evidence of TLR4 and TLR9 Variants Influencing Parasitaemia and Symptoms of Plasmodium vivax Infection

International Journal of Immunogenetics, Volume 52, Issue 6, Page 371-378, December 2025.
ABSTRACT Toll‐like receptors (TLRs) induce the production of pro‐inflammatory cytokines and regulate the immune response to Plasmodium vivax infection. Genetic variants of TLRs are associated with susceptibility and severity of malaria in different populations. This study aimed to evaluate the association between polymorphisms in TLR1, TLR4, TLR7, TLR8,
Mikaele Monik Rodrigues Inácio Silva, Gabriela Maria Andrade Correia, Juliana Dal‐Ri Lindenau, Maristela Gomes Cunha, Maria Deise Oliveira Ohnishi, Ana Maria Revoredo Silva Ventura, Ândrea Ribeiro‐dos‐Santos, Mara Helena Hutz, Vinicius Albuquerque Sortica   +8 more
wiley   +1 more source

World Association for Veterinary Dermatology Consensus Statement for Diagnosis, and Evidence‐Based Clinical Practice Guidelines for Treatment and Prevention of Canine Leishmaniosis

Veterinary Dermatology, Volume 36, Issue 6, Page 723-787, December 2025.
Hyperkeratosis of (a) the footpads and (b) the nasal planum. ABSTRACT Background Canine leishmaniosis (CanL) due to Leishmania infantum remains common, and veterinarians do not always follow scientifically sound approaches for diagnosis, treatment and prevention. Objectives To provide consensus guidelines for diagnosis and evidence‐based guidelines for
Manolis N. Saridomichelakis, Gad Baneth, Silvia Colombo, Filipe Dantas‐Torres, Lluís Ferrer, Alessandra Fondati, Guadalupe Miró, Laura Ordeix, Domenico Otranto, Chiara Noli   +9 more
wiley   +1 more source

Intervenções para cuidadores de sobreviventes de acidente vascular cerebral: revisão sistemática

Revista Panamericana de Salud Pública, 2018
Objetivo. Sintetizar e criticar a produção científica sobre as intervenções desenvolvidas para reverter a sobrecarga de cuidado e os fatores associados em cuidadores de sobreviventes de acidente vascular cerebral (AVC). Método.
Jaine Kareny da Silva, Karla Ferraz dos Anjos, Vanessa Cruz Santos, Rita Narriman Silva de Oliveira Boery, Darci de Oliveira Santa Rosa, Eduardo Nagib Boery   +5 more
doaj   +1 more source

Efficacy and Field Safety of Ilunocitinib for the Control of Allergic Dermatitis in Client‐Owned Dogs: A Multicenter, Double‐Masked, Randomised, Placebo‐Controlled Clinical Trial

Veterinary Dermatology, Volume 36, Issue 6, Page 825-837, December 2025.
Background: Inhibition of the Janus kinase pathway is an established treatment for allergic dermatitis. Objective: To evaluate the efficacy and safety of ilunocitinib for control of pruritus in dogs with allergic dermatitis in a randomised, double‐masked clinical trial.
Sophie Forster, Candace M. Trout, Simona Despa, Annette Boegel, Darren Berger, Stephen King   +5 more
wiley   +1 more source

Efficacy and field safety of ilunocitinib for the control of atopic dermatitis in client‐owned dogs: A multicentre, double‐masked, randomised, placebo‐controlled clinical trial

Veterinary Dermatology, Volume 36, Issue 5, Page 647-659, October 2025.
Background – Inhibition of the Janus kinase (JAK) pathway is a well‐established option for canine atopic dermatitis (cAD). Objective – To evaluate the efficacy and safety of ilunocitinib, a novel JAK inhibitor for the control of pruritus and skin lesions in client‐owned dogs with cAD.
Sophie Forster, Candace M. Trout, Simona Despa, Annette Boegel, Darren Berger, Stephen King   +5 more
wiley   +1 more source

Validation of the Equine Urticaria Activity Score for the assessment of chronic recurrent urticaria in horses

Veterinary Dermatology, Volume 36, Issue 5, Page 630-637, October 2025.
Background – Recurrent urticaria is common in horses. The pathophysiology is poorly understood and treatment options are limited. Often only glucocorticoids are effective for controlling clinical signs, albeit with potential adverse effects. Studies investigating new treatments need a validated objective scoring system for the grading of skin lesions ...
Katharina Birkmann, Nina Waldern, Simone Jucker, Katharina Balaschitsch, Yury Zablotski, Antonia Fettelschoss‐Gabriel   +5 more
wiley   +1 more source