Results 61 to 70 of about 13,747 (168)

Model‐based evaluation of the interaction between ritonavir‐boosted atazanavir and rifampicin in Ugandan adults with HIV

British Journal of Clinical Pharmacology, Volume 91, Issue 12, Page 3471-3481, December 2025.
Aim Concomitant treatment of tuberculosis (TB) and human immunodeficiency virus (HIV) is complicated by drug‐drug interactions (DDI). This analysis aimed to characterize the DDI between ritonavir‐boosted atazanavir (ATV/r) and rifampicin in plasma and peripheral blood mononuclear cells (PBMC).
Allan Kengo, Juan Eduardo Resendiz‐Galvan, Letisha Najjemba, Henry Mugerwa, Amedeo De Nicolò, Antonio D'Avolio, Shakir Atoyebi, Lubbe Wiesner, Elin M. Svensson, Catriona Waitt, Paolo Denti   +10 more
wiley   +1 more source

Blockchain como tecnologia para transparência de dados de ensaios clínicos [PDF]

, 2019
Introdução: Apesar dos recursos já existentes de regulação de registro e publicidade, é constatado que frequentemente os dados da pesquisa não são devidamente registrados.
Claudio Gottschalg Duque, Larissa F. Dos Angelos Cedro   +1 more
core  

Ensaios clínicos em Pediatria: aspetos eegulamentares e éticos [PDF]

, 2019
Tese de mestrado, Regulação e Avaliação do Medicamento e Produtos de Saúde, 2019, Universidade de Lisboa, Faculdade de Farmácia.Durante vários anos, os ensaios clínicos para o desenvolvimento de novos medicamentos foram realizados principalmente em ...
Luz, Filipa Augusto Guerreiro Quintela da
core   +2 more sources

New Evidence of TLR4 and TLR9 Variants Influencing Parasitaemia and Symptoms of Plasmodium vivax Infection

International Journal of Immunogenetics, Volume 52, Issue 6, Page 371-378, December 2025.
ABSTRACT Toll‐like receptors (TLRs) induce the production of pro‐inflammatory cytokines and regulate the immune response to Plasmodium vivax infection. Genetic variants of TLRs are associated with susceptibility and severity of malaria in different populations. This study aimed to evaluate the association between polymorphisms in TLR1, TLR4, TLR7, TLR8,
Mikaele Monik Rodrigues Inácio Silva, Gabriela Maria Andrade Correia, Juliana Dal‐Ri Lindenau, Maristela Gomes Cunha, Maria Deise Oliveira Ohnishi, Ana Maria Revoredo Silva Ventura, Ândrea Ribeiro‐dos‐Santos, Mara Helena Hutz, Vinicius Albuquerque Sortica   +8 more
wiley   +1 more source

World Association for Veterinary Dermatology Consensus Statement for Diagnosis, and Evidence‐Based Clinical Practice Guidelines for Treatment and Prevention of Canine Leishmaniosis

Veterinary Dermatology, Volume 36, Issue 6, Page 723-787, December 2025.
Hyperkeratosis of (a) the footpads and (b) the nasal planum. ABSTRACT Background Canine leishmaniosis (CanL) due to Leishmania infantum remains common, and veterinarians do not always follow scientifically sound approaches for diagnosis, treatment and prevention. Objectives To provide consensus guidelines for diagnosis and evidence‐based guidelines for
Manolis N. Saridomichelakis, Gad Baneth, Silvia Colombo, Filipe Dantas‐Torres, Lluís Ferrer, Alessandra Fondati, Guadalupe Miró, Laura Ordeix, Domenico Otranto, Chiara Noli   +9 more
wiley   +1 more source

Centros de ensaios clínicos: realidade ou ficção em Portugal [PDF]

, 2013
A investigação clínica é uma atividade fundamental para o desenvolvimento do conhecimento e inovação na área da saúde, que resulta do trabalho articulado entre várias entidades e pode incidir sobre indivíduos saudáveis, doentes, ou apenas utilizar ...
Torrão, João Gonçalo Saraiva
core  

Efficacy and Field Safety of Ilunocitinib for the Control of Allergic Dermatitis in Client‐Owned Dogs: A Multicenter, Double‐Masked, Randomised, Placebo‐Controlled Clinical Trial

Veterinary Dermatology, Volume 36, Issue 6, Page 825-837, December 2025.
Background: Inhibition of the Janus kinase pathway is an established treatment for allergic dermatitis. Objective: To evaluate the efficacy and safety of ilunocitinib for control of pruritus in dogs with allergic dermatitis in a randomised, double‐masked clinical trial.
Sophie Forster, Candace M. Trout, Simona Despa, Annette Boegel, Darren Berger, Stephen King   +5 more
wiley   +1 more source

Registro dos ensaios clínicos

Revista do Colégio Brasileiro de Cirurgiões
The International Committee of Medical Journal Editors (ICMJE) proposed trials registration in a public trials registry, as a condition for publication. This policy started after July 1, 2005, and was supported by the World Association of Medical Editors
Carlos Alberto Guimarães
doaj   +1 more source

Efficacy and field safety of ilunocitinib for the control of atopic dermatitis in client‐owned dogs: A multicentre, double‐masked, randomised, placebo‐controlled clinical trial

Veterinary Dermatology, Volume 36, Issue 5, Page 647-659, October 2025.
Background – Inhibition of the Janus kinase (JAK) pathway is a well‐established option for canine atopic dermatitis (cAD). Objective – To evaluate the efficacy and safety of ilunocitinib, a novel JAK inhibitor for the control of pruritus and skin lesions in client‐owned dogs with cAD.
Sophie Forster, Candace M. Trout, Simona Despa, Annette Boegel, Darren Berger, Stephen King   +5 more
wiley   +1 more source

Validation of the Equine Urticaria Activity Score for the assessment of chronic recurrent urticaria in horses

Veterinary Dermatology, Volume 36, Issue 5, Page 630-637, October 2025.
Background – Recurrent urticaria is common in horses. The pathophysiology is poorly understood and treatment options are limited. Often only glucocorticoids are effective for controlling clinical signs, albeit with potential adverse effects. Studies investigating new treatments need a validated objective scoring system for the grading of skin lesions ...
Katharina Birkmann, Nina Waldern, Simone Jucker, Katharina Balaschitsch, Yury Zablotski, Antonia Fettelschoss‐Gabriel   +5 more
wiley   +1 more source