Results 111 to 120 of about 6,523 (306)
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
ReQuEST: A Small-Scale Multi-Task Model for Community Question-Answering Systems
IEEE AccessThe burgeoning popularity of community question-answering platforms as an information-seeking strategy has prompted researchers to look for ways to save response time and effort, among which question entailment recognizing, question summarizing, and ...
Seyyede Zahra Aftabi +3 more
doaj +1 more source
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
, 2010 One outcome of the fourth in a series of Workshops on Reflection (as an approach to research), the production of a jointly authored subject matter, is discussed in terms of both Pask’s Entailment Meshes, and Schön’s Reflective Practice. A modification of
Glanville, Ranulph, Pak, Burak
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Entailment as Robust Self-Learner
, 2023 Entailment has been recognized as an important metric for evaluating natural language understanding (NLU) models, and recent studies have found that entailment pretraining benefits weakly supervised fine-tuning.
Glass, James +3 more
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Ubiquitination of secretory granules promotes their crinophagic degradation in Drosophila
FEBS Letters, EarlyView.Ubiquitination of secretory granules in Drosophila larval salivary glands is a critical molecular trigger for crinophagy, the lysosomal degradation of unreleased, or low‐quality granules. The E3 ubiquitin ligase Cnot4 is recruited to the surface of secretory granules to induce crinophagy.
Tamás Csizmadia +6 more
wiley +1 more source
An Entailment of Dead Days Comic
, 2017 The aim of this study was to analyze linguistic phenomenon of entailment in the Dead Days comic, the conversation all characters in Dead Days comic. This study had two objectives. They were to identify the types of entailment and the dominant types of
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Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Revisitando a Lógica de Dunn-Belnap
ManuscritoRESUMO O presente artigo apresenta uma semântica baseada nas atitudes cognitivas de aceitação e rejeição por uma sociedade de agentes para lógicas inspiradas no First Degree Entailment (E) de Dunn e Belnap.
Carolina Blasio
doaj +1 more source