Results 81 to 90 of about 6,523 (306)
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
, 2014 Lexical entailment is a requirement for success in the domains of Recognizing Textual Entailment (RTE) as well as related tasks like Question-Answering and Information Extraction.
Wieting, John
core
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Recognising Textual Entailment Focusing on Non-Entailing Text and Hypothesis
, 2008 This paper describes a predominantly shallow ap-proach to the rte-4 Challenge. We focus our at-tention on the non-entailing Text and Hypothesis pairs in the dataset. The system uses a Maximum Entropy framework to classify each pair of Text and Hypothesis
Nahnsen, Thade +3 more
core
Taking Defeasible Entailment beyond Rational Closure [PDF]
, 2019 peer reviewedWe present a systematic approach for extending the KLM framework for defeasible entailment. We first present a class of basic defeasible entailment relations, characterise it in three distinct ways and provide a high-level algorithm for ...
Ivan Varzinczak +5 more
core +1 more source
Entailment Relation Aware Paraphrase Generation
, 2022 We introduce a new task of entailment relation aware paraphrase generation which aims at generating a paraphrase conforming to a given entailment relation (e.g. equivalent, forward entailing, or reverse entailing) with respect to a given input.
Sancheti, Abhilasha +2 more
core +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Measuring the cognitive cost of downward monotonicity by controlling for negative polarity
Glossa, 2019 Our goal in this study was to behaviorally characterize the property (or properties) that render negative quantifiers more complex in processing compared to their positive counterparts (e.g. the pair few/many).
Galit Agmon +2 more
doaj +2 more sources
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source