Results 91 to 100 of about 89,426 (303)

Associação entre terapia nutricional, estado nutricional e tempo de ventilação mecânica em pacientes pediátricos graves [PDF]

, 2014
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde, Programa de Pós-Graduação em Nutrição, Florianópolis, 2014.Introdução: A desnutrição em pacientes pediátricos graves está associada com desfechos clínicos ...
Grippa, Rafaela Bouvie
core  

Outcomes in a pediatric intensive care unit before and after the implementation of a nutrition support team

, 2005
Background: We evaluated the effect of parenteral nutrition (PN) and enteral nutrition (EN) on in-pediatric intensive care unit (PICU) mortality before and after a continuous education program in nutrition support that leads to implementation of a ...
Heitor Pons Leite, Carvalho, W. B. de, Werther Brunow de Carvalho, Gurgueira, G. L., Leite, H. P., Taddei, JAC, Gisele Limongeli Gurgueira, José Augusto de Aguiar Carrazedo Taddei   +7 more
core   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

A multi-center, prospective, single-arm, open label, 13-month intervention study of a plant-based, high energy and protein enteral tube feed in home enterally tube fed patients

Frontiers in Nutrition
IntroductionThere is an emerging need for plant-based options for home enteral tube feeding (HETF) patients, however their long-term efficacy and safety needs to be established.MethodsForty-one HETF patients (age: 51 years (SD 23); range 19–84 years; 54%
Gary P. Hubbard, Corbin Griffen, Rebecca Capener, Nicky Wyer, Rebecca Martin, Rachel Raif, Lisa Green, Sheryl Sutcliffe, Elizabeth Michaels, Yvonne Dube, Johanna Bates, Alina Bidgood, Claudiu Brici, Daniel J. Griffith, Hannah Meanwell, Elizabeth Diamond, Charlotte Lennon, Louise Lewis, Lyndsay Chandler, Lisa Szymanski, Jane Ward, Cerian Banks, Katharine Nosworthy, Natasha Glanville, Sarah Richardson, Maura Hardy, Samantha Morris, Carys Robinson, Anna Lumsdon, Naomi Hatchett, Lindsey Allan, Robyn McNaughton, Alison Campbell, Janet Baxter, Stephanie Owen, Nola Blackburn, Emma Tripp, Helen Hitchings, Sheldon C. Cooper, Ann McCloskey, Heidi Lewis, Rebecca J. Stratton, Rebecca J. Stratton   +42 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Designing a precision-medicine platform trial to improve the nutritional care and intestinal health of very preterm babies: the COLLABORATE study

Efficacy and Mechanism Evaluation
Background Nutrition is essential for preterm brain development. Optimal nutrition is dependent upon gastrointestinal health. Primary objective To form a multiprofessional collaboration to design the world’s first neonatal precision-medicine platform ...
Neena Modi, Mohammad Chehrazi, James Boardman, Alan Boyd, Peter Bradley, Cecilia Cirelli, Stefano Giuliani, Lauren Ingledow, Caroline Lee-Davey, Paola Quattroni, Douglas Morrison, Colin Morgan, Ju-Lee Oei, Susan Ozanne, Kylie Pussell, Sabita Uthaya, Hilary Wong, Victoria Cornelius   +17 more
doaj   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source