Results 71 to 80 of about 29,427 (263)

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Transition phase of nutrition—optimizing nutrient administration

Frontiers in Pediatrics
This discussion explores the complex aspects of managing nutrition for preterm infants during the critical transition from exclusive parenteral nutrition (PN) to full enteral feeding (EN). The primary objectives of nutritional care in this very low birth
Pradeep Alur, Sumana Ramarao
doaj   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Observation of preparation and administration of drugs by nursing assistants in patients with enteral feeding tube

Brazilian Journal of Pharmaceutical Sciences, 2009
This study aimed to know the standard of preparation and administration of medicines to patients using probes of enteral nutrition (SNE) hospitalized in a university hospital in Porto Alegre.
Joana Heydrich, Isabela Heineck, Denise Bueno   +2 more
doaj   +1 more source

Enteral administration of the protease inhibitor gabexate mesilate preserves vascular function in experimental trauma/hemorrhagic shock. [PDF]

Sci Rep, 2023
J D Moreira N, Dos Santos F, Li JB, Aletti F, Irigoyen MCC, Kistler EB.   +5 more
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Beneficial effects of citrulline enteral administration on sepsis-induced T cell mitochondrial dysfunction. [PDF]

Proc Natl Acad Sci U S A, 2022
Reizine F, Grégoire M, Lesouhaitier M, Coirier V, Gauthier J, Delaloy C, Dessauge E, Creusat F, Uhel F, Gacouin A, Dessauge F, Le Naoures C, Moreau C, Bendavid C, Daniel Y, Petitjean K, Bordeau V, Lamaison C, Piau C, Cattoir V, Roussel M, Fromenty B, Michelet C, Le Tulzo Y, Zmijewski J, Thibault R, Cogné M, Tarte K, Tadié JM.   +28 more
europepmc   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

SIPPING ENTERAL NUTRITION: CLINICAL – PHARMACOLOGICAL ANALYSIS AND OPPORTUNITIES OF ITS USE IN THE INTENSIVE CARE

Вестник анестезиологии и реаниматологии, 2017
The article presents the results of comparative analysis of the 13 mixtures for sipping (oral) enteral feeding, most commonly used in RF, which are prescribed during the transfer from tube feeding to regular diet, and also when it is impossible to take ...
I. E. Khoroshilov
doaj   +1 more source