Results 191 to 200 of about 281,954 (293)

3D Bioprinted Blood–Brain–Tumor Barrier Spheroid‐Based In Situ Evaluation of Anticancer Compounds Against Glioblastoma: ROS‐Producing Ruthenium as a Potential Therapeutic Candidate

Advanced Science, EarlyView.
The blood–brain–tumor barrier (BBTB) penetration by anticancer drugs and their effects on glioblastoma (GBM) is assessed using 3D bioprinted‐spheroids. Anticancer drug‐induced U‐87 MG cell death is quantified through in situ imaging of spheroids using a cancer cell death probe. The Ru compound, a partial P‐gp substrate, induces greater tumor‐cell death
Hyunjung Lee, Chan Ho Jeon, Doyun Kim, Minjae Lee, Minji Kwon, Joon Myong Song   +5 more
wiley   +1 more source

Editorial: Assessing the environmental impact of ruminants: mitigation strategies and climate change implications. [PDF]

Front Microbiol
Cherdthong A, Foiklang S, Altermann E.
europepmc   +1 more source

Structural Variants in the Human Genome Associated With Gut Microbiome and Blood Metabolic Traits With Potential Causal Links

Advanced Science, EarlyView.
Based on a multi‐omics cohort of 2002 individuals comprising high‐depth whole‐genome and metagenomic sequencing data, blood metabolites, and detailed questionnaires, we identified 138 859 high‐confidence SVs, uncovering 36 significant SV–microbiome associations and 48 SV–blood metabolite associations.
Qun Zhou, Keqing Wang, Junhong Chen, Haoyu Wang, Xinjiang Tan, Xuanlin Huang, Zhiyin Lin, Xun Xu, Xin Jin, Shaoqiao Zhang, Liang Xiao, Yuanqiang Zou, Tao Zhang, Xiaomin Liu   +13 more
wiley   +1 more source

Biochemical discordance of a urinary fluoroquinolone-resistant <i>Escherichia coli</i> ST1193 as a <i>Shigella</i> species: A case report. [PDF]

IDCases
Peine B, Juan MRS, Choi H, Hwang M, Jinadatha C, Navarathna DH.   +5 more
europepmc   +1 more source

Meningeal Lymphatic LTBR Deficiency Links Spinal Cord Injury to Secondary Brain Pathology

Advanced Science, EarlyView.
Spinal cord injury (SCI) induces remote brain alterations beyond the injured spinal cord. This study links dysfunction of meningeal lymphatic vessels (mLVs) to neuroinflammation and neuronal injury after SCI. LTBR‐mediated lymphatic restoration improves meningeal lymphatic integrity and neurological outcomes, highlighting LTBR as a potential regulator ...
Yi Chen, Yu Tang, Chengpeng Hu, Xiaoyan Duan, LingXia Min, Boya Cong, Chao Ma, Mingliang Tan, Ya Luo, Pengfei Wei, Minpeng Xu, Zhou Feng, Jingming Hou   +12 more
wiley   +1 more source

Ionically Counter‐Programmable Phase‐Separation of Superstable Star‐Biopolyamide Coacervates for Electrothermally‐Responsive Pseudosolid Smart Windows

Advanced Science, EarlyView.
We develop bio‐based, star‐branched polyamides from itaconic acid and cadaverine with tunable lower critical solution temperature (LCST) transitions for dynamic solar modulation. Specific metal ion coordination with pyrrolidone moieties drives precise phase transitions via calcium‐induced salting‐in and sodium‐induced salting‐out mechanisms. Formulated
Jie Liu, Xiaotian Zhu, Jinjian Hou, Jinze Du, Mohammad Asif Ali, Maiko K. Okajima, Tatsuo Kaneko   +6 more
wiley   +1 more source

Fermented garlic as a functional food strategy for malnutrition: microbial ecology, bioactive compounds, and clinical perspectives. [PDF]

Front Nutr
Emmanuel-Fashagba MA, Obafemi YD, Oranusi SU.   +2 more
europepmc   +1 more source

Semi‐Artificial Photosynthesis Enables Light‐Driven Biomanufacturing in Non‐Photosynthetic Bacteria

Advanced Science, EarlyView.
A non‐invasive strategy exploits endogenous H2S metabolism in B. subtilis to drive in situ CdS biomineralization, enabling tight bio‐abiotic contact without genetic modification. Light harvested by the biomineralized nanoparticles powers NADPH regeneration, elevating 2’‐fucosyllactose and surfactin titres two‐ to three‐fold.
Jie Zheng, Anqi Tong, Wenxin Li, Meng Qiao, Yang Gu, Muhammad Sohail, Shan He, Sheng Yang, Xing Zhang   +8 more
wiley   +1 more source

The Carbon Footprint of Finishing Yearling Bulls Fed a Diet Containing Vegetable By-Products in Navarra, Spain. [PDF]

Animals (Basel)
González-Martínez P, Goenaga I, León-Ecay S, Mendizabal JA, Aldai N, Insausti K, Aldaya MM.   +6 more
europepmc   +1 more source

NCLX Inhibition plus Ca2+ Delivery Potentiates Electroporation and Antitumor Immunity in Pancreatic Ductal Adenocarcinoma

Advanced Science, EarlyView.
Electroporation combined with NCLX inhibition and Ca2+ delivery induces mitochondrial Ca2+ overload in PDAC cells, triggering pyroptosis, DAMP release, and antitumor immune activation. Simultaneously, suppression of tumor‐derived SPP1 weakens SPP1–CD44 signaling and remodels macrophages toward an antitumor phenotype, thereby enhancing CD8+ T‐cell ...
Chuanbing Zhao, Long He, Yu Lu, Zanglong Deng, Hongzhen Wei, Yunpeng Zhang, Ming Yang, Tao Yin   +7 more
wiley   +1 more source