Results 351 to 360 of about 1,557,903 (368)

Antithrombin: Deficiency, Diversity, and the Future of Diagnostics

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Our healthcare system provides reactive sick‐care, treating patients after symptoms have appeared by prescription of generic and often suboptimal therapy. This strategy brings along high costs and high pressure which is not sustainable.
Mirjam Kruijt, Christa M. Cobbaert, L. Renee Ruhaak   +2 more
wiley   +1 more source

Safety and Effect of 12‐Month Ecopipam Treatment in Pediatric Patients with Tourette Syndrome

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Tourette syndrome (TS) is a chronic neurodevelopmental tic disorder with a considerable quality of life (QOL) burden. Objectives The goal was to determine the long‐term safety, tolerability, and clinical effects of ecopipam, a first‐in‐class dopamine D1 receptor antagonist, for TS.
Donald L. Gilbert, David J.B. Kim, Meredith M. Miller, Sarah D. Atkinson, George B. Karkanias, Frederick E. Munschauer, Stephen P. Wanaski, Timothy M. Cunniff   +7 more
wiley   +1 more source

The Evolving Landscape of Immunotoxicity: Charting Mechanisms and Future Strategies for Immune Checkpoint Inhibitor Adverse Events

Med Research, EarlyView.
ABSTRACT The use of immune checkpoint inhibitors (ICIs) has significantly improved the efficacy of cancer therapy, but their associated immune‐related adverse events (irAEs) can severely compromise treatment safety. This review systematically summarizes the core mechanisms underlying irAEs, which include multi‐organ damage resulting from T‐cell ...
Anqi Lin, Keyin Zheng, Aimin Jiang, Xufeng Huang, Qi Wang, András Hajdu, Zhengrui Li, Jian Zhang, Peng Luo   +8 more
wiley   +1 more source

Critical care of the liver transplant patient [PDF]

, 1988
Esquivel, CO, Gordon, RD, Marsh, JW, Starzl, TE, Stieber, A   +4 more
core  

A Focus on Natural Autophagy Modulators as Potential Host‐Directed Weapons Against Emerging and Re‐Emerging Viruses

Medicinal Research Reviews, EarlyView.
ABSTRACT Autophagy is a highly conserved intracellular process involved in maintaining homeostasis and in the degradation of damaged organelles and external pathogens. Nature provides complex and varied reservoirs of scaffolds and chemical entities that may have a pivotal role in the search for new therapeutic leads.
Ilaria Cursaro, Sara Rossi, Stefania Butini, Sandra Gemma, Gabriele Carullo, Giuseppe Campiani   +5 more
wiley   +1 more source

Protective Effects of Human Milk Oligosaccharides (hMOs) on Analgesic, Nonsteroidal Anti‐inflammatory Drugs (NSAIDs)‐Induced Disruption of Gut Barrier Integrity in Cocultures Mimicking Neuro‐Gut Epithelial Cell Crosstalk

Molecular Nutrition &Food Research, EarlyView.
Nerve cells partially mitigate indomethacin‐induced tight junction dysregulation in neuro‐gut epithelial cell cocultures. Human milk oligosaccharides 2′‐ and 3‐fucosyllactose (2′‐FL and 3‐FL) protect the neuro‐gut epithelial barrier from indomethacin‐induced damage. This protection is stronger in cocultures with higher nerve cell densities.
Xiaochen Chen, Naschla Gasaly, Marthe T. C. Walvoort, Paul de Vos   +3 more
wiley   +1 more source

Two Ulcers on the Chin That Developed After Fever: Quiz Case

JEADV Clinical Practice, EarlyView.
Viktor Capiau, Sofie Engelen, An Van Laethem, Francesca Bosisio   +3 more
wiley   +1 more source

Subcutaneous Foslevodopa as Novel Rescue Therapy for Akinetic Crisis in Parkinson's Disease: A Case Report

Movement Disorders Clinical Practice, EarlyView.
Bendix Labeit, Julius Schulten, Alfons Schnitzler, Christian Johannes Hartmann   +3 more
wiley   +1 more source

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ESBL-producing strains isolated from imported cases of enteric fever in England and Wales reveal multiple chromosomal integrations of blaCTX-M-15 in XDR Salmonella Typhi.

Journal of Antimicrobial Chemotherapy, 2021
BACKGROUND There are approximately 300 cases of enteric fever reported annually from England and Wales; most are imported infections. Clinical management of enteric fever remains a challenge with the emergence of ESBL-producing strains, especially XDR ...
S. Nair, M. Chattaway, G. Langridge, A. Gentle, M. Day, Emma V Ainsworth, Iman Mohamed, R. Smith, C. Jenkins, T. Dallman, G. Godbole   +10 more
semanticscholar   +1 more source