Results 81 to 90 of about 17,304,241 (289)

Nutrient‐induced changes in the phenotype and function of the enteric nervous system

, 2014
International audienceThe enteric nervous system (ENS) integrates numerous sensory signals in order to control and maintain normal gut functions. Nutrients are one of the prominent factors which determine the chemical milieu in the lumen and, after ...
Schemann, Michael, Neunlist, Michel
core   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

SPG4 and Dementia: Expanding the Clinical Spectrum

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Hereditary spastic paraplegia (HSP) is a group of disorders characterized by progressive spasticity and lower limb weakness, with mutations in SPG4/SPAST being the most common cause. Detailed studies and clinical and molecular comparisons across different populations are missing.
Emanuele Panza, Arun Meyyazhagan, Eliseo Picchi, Gustavo Ribas, Ingrid Faber, Ryosuke Miyamoto, Preethi Basavaraju, Paolo Eusebi, Haripriya Kuchi Bhotla, Mario Stasi, Fabrizio Gaudiello, Francesco Patti, Filippo Maria Santorelli, Marcondes Cavalcante França Jr, José Luiz Pedroso, Orlando Graziani Povoas Barsottini, Hélio Afonso Ghizoni Teive, Peter Henry St George‐Hyslop, Toshitaka Kawarai, Antonio Orlacchio   +19 more
wiley   +1 more source

How leaky is the gut in Parkinson’s disease?

EBioMedicine
Summary: The intestinal epithelial barrier (IEB) plays a critical role in health and disease by regulating the absorption of nutrients, electrolytes and water while preventing gut translocation of pathogens.
Pascal Derkinderen, François Cossais, Kristína Kulcsárová, Matej Škorvánek, Loïc Sellier-Montaigne, Emmanuel Coron, Laurène Leclair-Visonneau, Silvia Cerri, Carolina Pellegrini, Malvyne Rolli-Derkinderen   +9 more
doaj   +1 more source

Induced pluripotent stem cell-derived enteric neural crest cells repopulate human aganglionic tissue-engineered intestine to form key components of the enteric nervous system

Journal of Tissue Engineering, 2020
Models for enteric neuropathies, in which intestinal nerves are absent or injured, are required to evaluate possible cell therapies. However, existing options, including transgenic mice, are variable and fragile.
David F Chang, Samuel M Zuber, Elizabeth A Gilliam, Laura-Marie A Nucho, Gabriel Levin, Fengnan Wang, Anthony I Squillaro, Sha Huang, Jason R Spence, Tracy C Grikscheit   +9 more
doaj   +1 more source

Maternal protein restriction induces gastrointestinal dysfunction and enteric nervous system remodeling in rat offspring.

, 2019
International audienceEarly-life adversity is a major risk factor for the development of diseases later in life. Maternal protein restriction (MPR) is associated with morbidities in offspring affecting multiple organs, but its impact on the ...
Le Dréan, Gwenola, Grohard, Pierre Antoine, Ndjim, Marième, Boudin, Hélène, Chevalier, Julien, Neunlist, Michel, Le Berre-Scoul, Catherine, Aubert, Philippe, Oleynikova, Elena, Rizvi, Hina, Segain, Jean-Pierre   +10 more
core   +1 more source

Longitudinal Assessment of Biomarkers in ALS: Discriminative Biomarkers for Disease Progression and Survival

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To assess the association and discriminative performance of serum biomarkers with clinical disease progression and survival in patients with amyotrophic lateral sclerosis (ALS). Methods This retrospective study, conducted at Houston Methodist Hospital, Houston, TX, used longitudinal serum samples collected between January 2018 and ...
David R. Beers, Yueh‐Yun Lin, Jason R. Thonhoff, Aaron D. Thome, Alireza Faridar, Weihua Zhao, Shixiang Wen, Stanley H. Appel   +7 more
wiley   +1 more source

Ofatumumab in Myelin Oligodendrocyte Glycoprotein Antibody–Associated Disease: A Comparison With Rituximab

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate the efficacy and safety of ofatumumab in patients with myelin oligodendrocyte glycoprotein antibody–associated disease (MOGAD), and compare it with rituximab. Methods We conducted a single–center, observational study including 22 MOGAD patients treated with ofatumumab and 21 treated with rituximab.
Yuxin Fan, Lei Zhou, Jingzi ZhangBao, Hongmei Tan, Zhouzhou Wang, Chao Quan   +5 more
wiley   +1 more source

Microbial metabolites alleviate Aß-induced alterations of intestinal epithelial barrier and enteric nervous system connectivity

Journal of Functional Foods
Amyloid-ß (Aß) induced alterations in gut functions, such as reduced motility and compromised barrier integrity contribute to age-related frailty. Therefore, developing fermentation-based products to prevent age-related gut disorders represents a major ...
Rodrigue Brossaud, Valentine S. Moullé, Marina Giblaine, Sergine Even, Marie-Bernadette Maillard, Séverine Chevalier, Thibauld Oullier, Eric Guédon, Yves Le Loir, Moustapha Cissé, Hélène Falentin, Michel Neunlist   +11 more
doaj   +1 more source

Opportunities and Challenges for Single-Unit Recordings from Enteric Neurons in Awake Animals

Micromachines, 2018
Advanced electrode designs have made single-unit neural recordings commonplace in modern neuroscience research. However, single-unit resolution remains out of reach for the intrinsic neurons of the gastrointestinal system.
Bradley B. Barth, Hsin-I Huang, Gianna E. Hammer, Xiling Shen   +3 more
doaj   +1 more source