Results 61 to 70 of about 17,304,241 (289)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Contacting the gut: Mitochondria-associated Endoplasmic Reticulum Membranes in the Enteric Nervous System

Contact
Changes in the connections between the endoplasmic reticulum (ER) and mitochondria, as well as alterations in mitochondria-associated ER membrane (MAM) signalling, have been documented in various neurodegenerative diseases affecting the brain.
Jenny Greig, Giada Delfino, Pascal Derkinderen, Sébastien Paillusson   +3 more
doaj   +1 more source

Role of ICAM-1 in the Adhesion of T Cells to Enteric Glia: Perspectives in the Formation of Plexitis in Crohn’s DiseaseSummary

Cellular and Molecular Gastroenterology and Hepatology
Background & Aims: The presence of myenteric plexitis in the proximal resection margins is a predictive factor of early postoperative recurrence in Crohn’s disease.
Julie Pabois, Tony Durand, Catherine Le Berre, Rhiannon T. Filippone, Théo Noël, Emilie Durieu, Céline Bossard, Sarah Bruneau, Malvyne Rolli-Derkinderen, Kulmira Nurgali, Michel Neunlist, Arnaud Bourreille, Isabelle Neveu, Philippe Naveilhan   +13 more
doaj   +1 more source

Distribution and trafficking of the μ-opioid receptor in enteric neurons of the guinea pig

, 2016
© 2016 the American Physiological Society. The μ-opioid receptor (MOR) is a major regulator of gastrointestinal motility and secretion and mediates opiate-induced bowel dysfunction.
Canals, Meritxell, Joslyn Lay, Carbone, Simona E., Meritxell Canals, Poole, Daniel P., Nigel W. Bunnett, Jesse J. DiCello, DiCello, Jesse J., Daniel P. Poole, Bunnett, Nigel W., Lay, Joslyn, Simona E. Carbone   +11 more
core   +1 more source

Stress, sex, and the enteric nervous system. [PDF]

, 2016
Made up of millions of enteric neurons and glial cells, the enteric nervous system (ENS) is in a key position to modulate the secretomotor function and visceral pain of the gastrointestinal tract.
Larauche, Muriel, Million, M
core   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Enteric nervous system: Neurotrophic factors

, 2009
The enteric nervous system (ENS) is the most complex region of the peripheral nervous system. The roles of neurotrophic factors in the early development of the ENS are relatively well established.
Saffrey, Jill, M.J. Saffrey
core   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Histological Processing of Organoids for Immunostaining

Bio-Protocol
Organoids are three-dimensional cell structures derived from stem cells that recapitulate the architecture and function of native tissues. Histological analysis of organoids is essential for assessing their structure, cellular composition, and responses ...
Lisa Brossard, Victor Perreaux, Simon Vales, Lola Bonneau, Sarah Godin, Anne Bibonne, Theo Noël, Laura Bachir, Archie Khan, Guillaume Lamirault, Anne Gaignerie, Nathalie Gaborit, Maxime Mahe   +12 more
doaj   +1 more source

Optimizing Western Blots for the Detection of Endogenous α-Synuclein in the Enteric Nervous System [PDF]

, 2015
Background:Alpha-synuclein containing inclusions in neurons, the characteristic pathological lesions of Parkinson’s disease (PD), are not limited to the central nervous system, but also affect the enteric nervous system (ENS).
G. Balloy, Corbillé, Anne-Gaëlle, Balloy, Gaëlle, A.G. Corbillé, Preterre, Cécile, Letournel, Franck, F. Letournel, Neunlist, Michel, P. Derkinderen, Derkinderen, Pascal, C. Preterre, M. Neunlist   +11 more
core   +1 more source