Results 41 to 50 of about 17,304,241 (289)

Elevated levels of colonic interleukin-1beta and interleukin-8 in isolated REM sleep behavior disorder without associated changes in permeability

npj Parkinson's Disease
Gastrointestinal inflammation could contribute to the early development of Parkinson’s disease (PD). This study investigated gut inflammation, intestinal barrier function, and integrity in patients with isolated REM sleep behavior disorder (iRBD), a ...
Loïc Sellier Montaigne, Simon Lassozé, Adrien de Guilhem de Lataillade, Thibauld Oullier, Marie-Anne Vibet, Kalyane Bach-Ngohou, Malvyne Rolli-Derkinderen, Tony Durand, Séverine Le Dily, Iva Jirka-Alebic, Emmanuel Coron, Quentin Michaux, Michel Neunlist, Giuseppe Madaro, Alessandra Cervino, Pascal Derkinderen, Laurène Leclair-Visonneau   +16 more
doaj   +1 more source

The enteric nervous system : new developments and emerging concepts [PDF]

, 2011
The enteric nervous system (ENS) is an integrative neuronal network, organized in two ganglionated plexuses, myenteric and submucosal, composed of neurons and enteric glial cells, controlling the activity of the smooth muscle of the gut, mucosal ...
Serio, Rosa, Mastropaolo, Mariangela, Garzia Zizzo, Maria, ZIZZO, Maria Grazia, SERIO, Rosa Maria   +4 more
core  

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Impact of Siponimod on Enteric and Central Nervous System Pathology in Late-Stage Experimental Autoimmune Encephalomyelitis. [PDF]

, 2022
Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS). Although immune modulation and suppression are effective during relapsing-remitting MS, secondary progressive MS (SPMS) requires neuroregenerative therapeutic options ...
Bigaud, Marc, Michael Enders, Christopher Kapitza, Marc Bigaud, Kirchner, Philipp, Kuerten, Stefanie, Ekici, Arif, Enders, Michael, Kapitza, Christopher, Philipp Kirchner, Wörl, Jürgen, Stefanie Kuerten, Arif Ekici, Jürgen Wörl, Alicia Weier, Weier, Alicia   +15 more
core   +2 more sources

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Tumor cells hijack enteric glia to activate colon cancer stem cells and stimulate tumorigenesisResearch in context

EBioMedicine, 2019
Background: Colon cancer stem cells (CSCs), considered responsible for tumor initiation and cancer relapse, are constantly exposed to regulatory cues emanating from neighboring cells present in the tumor microenvironment.
Simon Valès, Gregory Bacola, Mandy Biraud, Mélissa Touvron, Anne Bessard, Fanny Geraldo, Kelsie A. Dougherty, Shaian Lashani, Céline Bossard, Mathurin Flamant, Emilie Duchalais, Séverine Marionneau-Lambot, Thibauld Oullier, Lisa Oliver, Michel Neunlist, François M. Vallette, Laurianne Van Landeghem   +16 more
doaj   +1 more source

Effects of the Autonomic Nervous System, Central Nervous System and Enteric Nervous System on Gastrointestinal Motility [PDF]

, 2014
The gastrointestinal tract is chiefly involved in the digestion of ingested food, facilitation of absorption process and expulsion of the undigested food material through motility process.
Reddy, PMK
core   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source