Results 91 to 100 of about 88,864 (361)

A FILTERABLE VIRUS CAUSING ENTERITIS AND PNEUMONIA IN CALVES [PDF]

Journal of Experimental Medicine, 1943
An infectious disease of calves has been described which is characterized by fever, diarrhea, and pneumonia, followed soon by recovery. On autopsy of animals killed at the height of the disease, there is found a catarrhal enteritis and a bronchopneumonia that is usually confined to the anterior lobes of the lungs.
openaire   +3 more sources

Enteritis due to Feline Infectious Peritonitis Virus

The Japanese Journal of Veterinary Science, 1982
臨床・病理・血清学的にネコ伝染性腹膜炎(FIP)と診断され死亡したネコ4例および仔ネコの実験接種例14例について, 腸病変とウイルス抗原あるいはウイルス粒子の所在を検索した. 自然例2例および実験例12例が下痢を発した. 多くの病例の小腸・大腸粘膜は水腫性に肥厚し, 腸内容は水様～粘液状であった. 自然例3例および実験例12例の小腸・大腸病変は粘膜上皮の変性・剥離・増生を特徴とする比較的表在性の変化で, 固有層には浮腫, 少数の好中球お上び単核細胞浸潤がみられ, 隣接上皮細胞相互の癒合もしばしばみとめられた. しかし, 他の自然例1例および実験死亡例2例では, 小腸・大腸ともに炎症病変は激しく粘膜深部に及んでいた.
Yoshinori Watabe, Toshiharu Hayashi, Hiroyuki Nakayama, Kosaku Fujiwara   +3 more
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Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Isohemagglutinins of Graft Origin after ABO-Unmatched Liver Transplantation [PDF]

, 1984
THE increasing success of liver transplantation in recent years has provided an experimental model to study and document the hepatic synthesis of many plasma proteins.12345 The normal hepatobiliary tract has not been regarded as a major source of ...
Anderson, Bird, Borel, Glenn Ramsey, Gwenn D. Lindsay, Jacob Nusbacher, Kukral, Lindsey, Lundgren, Marchioro, Rannie, Shaw, Starzl, Thomas E. Starzl   +13 more
core   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Simian Varicella Virus Infects Enteric Neurons and α4β7 Integrin-Expressing Gut-Tropic T-Cells in Nonhuman Primates

Viruses, 2018
The pathogenesis of enteric zoster, a rare debilitating complication of reactivation of latent varicella-zoster virus (VZV) in the enteric nervous system (ENS), is largely unknown.
Werner J. D. Ouwendijk, Suzanne van Veen, Tamana Mehraban, Ravi Mahalingam, Georges M. G. M. Verjans   +4 more
doaj   +1 more source

Molecular characterization of the duck enteritis virus US10 protein [PDF]

Virology Journal, 2017
There is little information regarding the duck enteritis virus (DEV) US10 gene and its molecular characterization.Duck enteritis virus US10 was amplified and cloned into the recombinant vector pET32a(+). The recombinant US10 protein was expressed in Escherichia coli BL21 cells and used to immunize rabbits for the preparation of polyclonal antibodies ...
Mafeng Liu, Qiao Yang, Shun Chen, Ying Wu, Mingshu Wang, Daixi Zhang, Kunfeng Sun, Maoyin Lai, Dekang Zhu, Anchun Cheng, Xiaoyue Chen, Renyong Jia, Xinxin Zhao   +12 more
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Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Molecular characterization of duck enteritis virus UL41 protein [PDF]

Virology Journal, 2018
Duck enteritis virus (DEV) belongs to the subfamily Alphaherpesvirinae, and information on the DEV UL41 gene is limited.The DEV UL41 gene was cloned into the pET32a(+) vector and expressed in a prokaryotic expression system. Antiserum was raised against a bacterially expressed UL41-His fusion protein for further experiments.
Xiaoyue Chen, Ying Wu, Dekang Zhu, Mingshu Wang, Xinxin Zhao, Tianqiong He, Mafeng Liu, Renyong Jia, Xuelian Cao, Qiao Yang, Kunfeng Sun, Shun Chen, Anchun Cheng   +12 more
openaire   +4 more sources

Characterization of WAC interactions with R2TP and TTT chaperone complexes linking glucose and glutamine availability to mTORC1 activity

FEBS Open Bio, EarlyView.
TTT and R2TP chaperone complexes are required for the assembly and activation of mTORC1. WAC directly interacts with components of TTT, R2TP, and mTORC1, and these interactions are affected by the availability of glucose and glutamine, correlating with changes in mTORC1 activity.
Sofía Cabezudo, Natalia Cuervo, Carmen García‐Martín, Andrés López‐Perrote, Clara Reglero, Adrián Maqueda‐Real, Ana González‐Corpas, Marina Serna, Diego Megías, Alejo Efeyan, Solip Park, Oscar Llorca   +11 more
wiley   +1 more source