Results 141 to 150 of about 1,217,622 (299)

VP3 is crucial for the stability of Nora virus virions

, 2016
Nora virus is an enteric virus that causes persistent, non-pathological infection in Drosophila melanogaster. It replicates in the fly gut and is transmitted via the fecal-oral route.
Hultmark, Dan,, Hultmark, Dan, Venkateswara Rao, Jonna, Sadanandan, Sajna Anand, Ekström, Jens-Ola,, Sadanandan, Sajna Anand,, Hofer, Anders,, Hofer, Anders, Ekström, Jens-Ola, Jonna, Venkateswara Rao,   +9 more
core   +1 more source

Disrupted TFEB/GDNF–cAMP/ATP Coupling Underlies Astrocytic Dysfunction and Depression in LRRK2 G2019S Parkinson's Mice

Advanced Science, EarlyView.
ABSTRACT The LRRK2 G2019S mutation, a Parkinson's disease–linked variant, has been associated with depression‐like phenotypes, but mechanisms remain unclear. We chart age‐dependent behavioral changes and astrocyte reactivity in G2019S mice and define a pathway connecting LRRK2 to TFEB/GDNF signaling, cellular energetics, and inflammation.
Longping Yao, Maryam Hatami, Sumeyye Koc, Qing Jiang, Thomas Skutella, Yuanfeng Zhang   +5 more
wiley   +1 more source

Experimental and CFD evaluation of ozone efficacy against coronavirus and enteric virus contamination on public transport surfaces. [PDF]

J Environ Chem Eng, 2021
Falcó I, Randazzo W, Sánchez G, Vilarroig J, Climent J, Chiva S, Chica A, Navarro-Laboulais J.   +7 more
europepmc   +1 more source

Underground Signals: The Ecological Power of Root Volatiles

Advanced Science, EarlyView.
Root volatiles mediate rhizosphere chemical communication, shaping interactions among plants, microbes, herbivores, and natural enemies. Their production, transport, and perception underpin ecological adaptation, multitrophic interactions, and plant resilience, offering opportunities for sustainable crop protection, resilient agroecosystems, and ...
Xueyao Cao, Nanli Song, François Verheggen, Meritxell Pérez‐Hedo, Andrea Clavijo McCormick, Antonino Cusumano, Arthur de Fouchier, Bing Wang, Chen‐Zhu Wang, Emmanuelle Jacquin‐Joly, Gary W. Felton, Geoff M. Gurr, Hao Guo, Jiancai Li, Jin Zhang, Li Chen, Manqun Wang, Michele Ricupero, Peng Han, Peng He, Qi Yan, Qingbo Tang, Qingsong Liu, Shiheng An, Xiangbo Kong, Xiaoling Sun, Xueming Ren, Yuanyuan Song, Yang Liu, Yanhui Guo, Yunhe Li, Xiao Sun   +31 more
wiley   +1 more source

The Intestinal Microbiome Primes Host Innate Immunity against Enteric Virus Systemic Infection through Type I Interferon. [PDF]

mBio, 2021
Yang XL, Wang G, Xie JY, Li H, Chen SX, Liu W, Zhu SJ.   +6 more
europepmc   +1 more source

Targeted Restoration of the Microbial Tryptophan Oxidative Pathway Ameliorates Autism‐Like Behavioral and Synaptic Deficits

Advanced Science, EarlyView.
ABSTRACT Autism Spectrum Disorder (ASD) is associated with gut microbiota dysbiosis, yet the contribution of specific microbial metabolic pathways remains unclear. Reanalysis of a public ASD cohort revealed reduced functional potential in microbial tryptophan oxidative metabolism.
Rui Guo, Caian He, Xiao Xiao, Jingmeng Li, Zilong Zhang, Ying He, Chuanchuan Wang, Jiale Zhao, Jun Gong, Jiarui Liang, Tian Yuan, Haiting Sun, Xuebo Liu, Chao Gao, Zhigang Liu   +14 more
wiley   +1 more source

Characterization of the enteric virome of clinically healthy pigs around weaning on commercial farms in the Netherlands using next generation sequencing and qPCR

Porcine Health Management
Background Enteric virus infections around time of weaning have always been related to pig diseases such as postweaning diarrhea. Little, however, is known about the virus infection pattern (species, timing and viral load) in clinically healthy pigs ...
M.A.R. Schyns, R. van den Braak, J. Peijnenborg, S. Coppens, M. Deijs, M. G.J.M. Burggraaff, W. I. Kuller, S. Theuns, L. van der Hoek, A. de Groof   +9 more
doaj   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Pediatric Respiratory and Enteric Virus Acquisition and Immunogenesis in US Mothers and Children Aged 0-2: PREVAIL Cohort Study. [PDF]

JMIR Res Protoc, 2021
Morrow AL, Staat MA, DeFranco EA, McNeal MM, Cline AR, Conrey SC, Schlaudecker EP, Piasecki AM, Burke RM, Niu L, Hall AJ, Bowen MD, Gerber SI, Langley GE, Thornburg NJ, Campbell AP, Vinjé J, Parashar UD, Payne DC.   +18 more
europepmc   +1 more source

Microglial Deubiquitinase OTUD7B Stabilizes STAT3 to Promote Neuroinflammation and Cognitive Decline in Alzheimer's Disease

Advanced Science, EarlyView.
. ABSTRACT Neuroinflammation driven by microglial activation is a defining feature of Alzheimer's disease (AD), yet the molecular mechanisms sustaining this proinflammatory state remain unclear. Here, we identify the deubiquitinase OTUD7B as a critical regulator of microglial activation and AD pathology.
Luyao Li, Hao Tang, Qin Yu, Yuyang Zhang, Binglu Shi, Ying Kong, Leiyu Xu, Jingjing Shao, Chenghong Hu, Lingyu She, Zhe Wang, Haiyi Chen, Aleksandr V. Samorodov, Gang Cao, Xia Zhao, Yi Wang   +15 more
wiley   +1 more source