Results 281 to 290 of about 90,716 (312)

Targeting WEE1 in ARID1A/TP53 Concurrent Mutant Colorectal Cancer by Exploiting R‐Loop Accumulation and DNA Repair Deficiencies

Advanced Science, EarlyView.
ARID1A, a SWI/SNF complex component, is frequently mutated in colorectal cancer (CRC). CRC with ARID1A/TP53 concurrent mutations shows marked sensitivity to WEE1 inhibition. ARID1A loss induces R‐loop‐mediated replication stress, impairs ATF3 transcription, and amplifies WEE1i‐induced DNA damage, suggesting a promising therapeutic vulnerability ...
Chi Zhang, Yanjing Zhu, Luoyan Ai, Jingyuan Wang, Shan Yu, Yichen Wang, Xiaojing Xu, Mengling Liu, Yiyi Yu, Mengxuan Zhu, Yutong Liu, Zhenghang Xu, Haojie Zhou, Huishan Li, Qihong Huang, Qing Liu, Ke Peng, Tianshu Liu   +17 more
wiley   +1 more source

The essential role of heparan sulfate in the entry of PDCoV and other porcine coronaviruses. [PDF]

Virulence
Ma N, Zhang M, Ghonaim AH, Zhou P, Wang C, Zhou J, Guo G, Lebbink RJ, Bosch BJ, Zhu H, Li W, He Q.   +11 more
europepmc   +1 more source

A Lung‐Immune Dual‐Humanized Mouse Using Cryopreserved Tissue Enables Infection and Immune Profiling of Human Common Cold Coronaviruses

Advanced Science, EarlyView.
Cryopreserved lung‐humanized mice overcome the dependency to fresh tissues and permit head‐to‐head profiling of all four human common cold coronaviruses versus SARS‐CoV‐2 infection; the model validates Paxlovid efficacy against HKU1 and, when coupled with human immune‐system engraftment, enables interrogation of lung‐resident human immunity and HKU1 ...
Chunyu Cheng, Jing Sun, Chun Lu, Qian Yu, Yiyun He, Bingqing Wu, Deshan Ren, Shuai Ding, Jincun Zhao, Yan Li   +9 more
wiley   +1 more source

Gene Therapy in Crohn's Disease: Current Preclinical Challenges and Future Translational Avenues. [PDF]

Biomedicines
Abdalla S, Brouquet A, Aron-Badin R, Bougnères P.   +3 more
europepmc   +1 more source

Molecular epidemiology of viral enteric in children in Hangzhou. [PDF]

BMC Infect Dis
Chen BH, Lai QR, Chen YY, Zhou HY, Cai DT, Shen HQ, Li W.   +6 more
europepmc   +1 more source

Annual Report Concerning Foodborne Disease in New Zealand, 2009 [PDF]

, 2010
Cressey, Peter, Lim, Esther, Pirie, Ruth, Tisch, Catherine   +3 more
core  

Intestinal microbiota dynamics in piglets: the interplay with swine enteric coronavirus infections and implications for disease control. [PDF]

Anim Microbiome
Liu Y, Dong B, Yang YL, Zhang YQ, Zhang Y, Pan D, Du EZ, Zhu SJ, Wang B, Huang YW.   +9 more
europepmc   +1 more source

The etiology of acute infectious febrile illnesses at a tertiary care hospital: an experience from a hilly region of Uttarakhand. [PDF]

Iran J Microbiol
Rawat Y, Pal S, Negi A, Husain U, Nath R, Negi N.   +5 more
europepmc   +1 more source

Treatment and hygiene of farm slurry and food waste [PDF]

Mohaibes, Mohammed
core