Results 91 to 100 of about 364,513 (253)

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Demographic characteristics and detection of enteric viruses among patients with diarrhea, Lwak and Kibera, Kenya.

, 2016
Demographic characteristics and detection of enteric viruses among patients with diarrhea, Lwak and Kibera, Kenya.
Leonard Cosmas (319756), Umesh D. Parashar (143035), Nicole Gregoricus (161222), Aron J. Hall (436912), Jan Vinjé (2851898), Daniel R. Feikin (153640), Kayoko Shioda (3172524), Joel M. Montgomery (268586), Robert F. Breiman (153635), Allan Audi (310313)   +9 more
core   +1 more source

Simultaneous detection and identification of enteric viruses by PCR-mass assay. [PDF]

, 2012
Simultaneous detection of enteric viruses that cause similar symptoms (e.g. hand, foot and mouth disease) is essential to the prevention of outbreaks and control of infections.
Licheng Liu (149224), Yanfang Guan, Jingzi Piao (149211), Jingzi Piao, Hua Jiang, Jun Jiang (149215), Hua Jiang (123031), Weili Wu, Jinyin Zhao, Yuan Zhang (41832), Licheng Liu, Yongqiang Jiang (123029), Yongqiang Jiang, Yinhui Yang, Xiaohong Wang, Yan Li (23143), Bianli Xu (149218), Yuling Zheng, Xueyong Huang (149227), Yuan Zhang, Pengzhi Wang (149230), Weili Wu (46711), Bianli Xu, Yan Li, Jun Jiang, Jinyin Zhao (149232), Yanfang Guan (149221), Xueyong Huang, Yuling Zheng (123026), Yinhui Yang (149240), Xiaohong Wang (93777), Weijun Chen (149241), Pengzhi Wang, Xiaoping Kang, Weijun Chen, Yuanyin Cao, Xiaoping Kang (149234), Yuanyin Cao (149236), Wang Xiaohong, Wu Weili, Jiang Jun, Jiang Hua, Zheng Yuling, Huang Xueyong, Liu Licheng, Zhang Yuan, Chen Weijun, Li Yan, Cao Yuanyin, Zhao Jinyin, Yang Yinhui, Guan Yanfang, Piao Jingzi, Jiang Yongqiang, Xu Bianli, Kang Xiaoping, Wang Pengzhi   +56 more
core   +1 more source

USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival

Molecular Oncology, EarlyView.
CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna, Jodie Hay, Michael W. Moles, Lucy Clarke, Jennifer Cassels, Alison Sefcick, Alison M. McCaig, Heather G. Jørgensen, Alison M. Michie   +8 more
wiley   +1 more source

Emerging and potentially emerging viruses in water environments

Annali dell'Istituto Superiore di Sanità, 2012
Among microorganisms, viruses are best fit to become emerging pathogens since they are able to adapt not only by mutation but also through recombination and reassortment and can thus become able to infect new hosts and to adjust to new environments ...
Giuseppina La Rosa, Marta Fratini, Simonetta della Libera, Marcello Iaconelli, Michele Muscillo   +4 more
doaj   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

‘Don’t put your head under water’: enteric viruses in Brazilian recreational waters

New Microbes and New Infections, 2019
Like in many other countries, virologic analyses are not routinely performed in Brazil in monitoring water quality for recreational purposes. We surveyed current research regarding viral contamination of recreational water environments in Brazil.
V. Girardi, M. Demoliner, J.S. Gularte, F.R. Spilki   +3 more
doaj   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Identification of (20R)‐protopanaxadiol from Panax ginseng as a novel anti‐SARS‐CoV‐2 compound

FEBS Open Bio, EarlyView.
We established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Midori Takeda, Natsue Maezono, Rina Uchikoshi, Nobuyuki Kato, Masanori Ikeda   +4 more
wiley   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source