Results 71 to 80 of about 20,164 (264)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Study of the Antioxidant and Antibacterial Effects of Genipa americana L. Against Food Pathogens

Foods
This study presents the chemical profile of the ethanolic extract of Genipa americana L. stem bark and the evaluation of its antibacterial and antioxidant activities. The chemical prospecting consisted of a qualitative analysis and quantification by HPLC-
Lariza Leisla Leandro Nascimento, Geane Gabriele de Oliveira Souza, Ana Cecília Calixto Donelardy, Maria Inácio da Silva, Cícera Alane Coelho Gonçalves, Ana Maria Duarte Fernandes, José Walber Gonçalves Castro, Débora Odília Duarte Leite, Irwin Rose Alencar de Menezes, José Galberto Martins da Costa, Fabíola Fernandes Galvão Rodrigues   +10 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Microbiological quality of marketed fresh and frozen seafood caught off the Adriatic coast of Croatia

Veterinární Medicína, 2010
Fresh and frozen seafood products (fish, shellfish, crustaceans, molluscs) in wide use in Croatia and typical of the Mediterranean diet, were examined for the presence of microbiological contamination through the winter and summer seasons.
N. Topic Popovic, A. Benussi Skukan, P. Dzidara, R. Coz-Rakovac, I. Strunjak-Perovic, L. Kozacinski, M. Jadan, D. Brlek-Gorski   +7 more
doaj   +1 more source

[Interpretive reading of enterobacteria antibiograms].

Enfermedades infecciosas y microbiologia clinica, 2010
The resistance pattern observed in the antibiogram of an isolate should be the sum of its natural resistance pattern, characteristic of the species, plus the acquired resistances. In Enterobacteriaceae, the production of inactivating enzymes is the main mechanism of resistance to beta-lactams and aminoglycosides.
Navarro, F, Miro, E, Mirelis, B
openaire   +2 more sources

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Bacteriemia por enterobacterias en adultos en un hospital universitario: análisis de cinco años Bacteremia by enterobacteria in adults from a university hospital: a five year analysis

Revista Argentina de Microbiología, 2007
La bacteriemia sigue siendo una de las causas más importantes de morbilidad y mortalidad en pacientes adultos, a pesar de los numerosos antimicrobianos hoy disponibles y del aumento de las medidas de soporte. El objetivo del presente estudio fue analizar
A. V. Ocaña Carrizo, M. Rocchi, A. Gasparotto, I. Conrero, M. Navarro, S. Factorovich, C. Albrecht, A. Monterisi   +7 more
doaj  

The Enterobacteria, 2nd Edition

Gut, 2007
Edited by J Michael Janda, Sharon L Abbott. Washington: ASM Press, 2006, £87 (hardback), pp 411. ISBN 978-1-55581-342-0 As a microbiologist, having collaborated with quite a few gastroenterologists and gastrointestinal surgeons on past and current research projects, I am convinced most, if not all, have a great interest in bacterial infection.
openaire   +2 more sources