Results 121 to 130 of about 4,145 (297)
Characterization of extended spectrum β-lactamases in Colombian clinical isolates of non-typhoidal Salmonella enterica between 1997 and 2022 [PDF]
Biomedica, 2023 Rodríguez EC +7 more
europepmc +1 more source
Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
Introducción: la resistencia bacteriana es un problema de salud pública mundial en contextos comunitarios y hospitalarios, influenciado por factores humanos, ambientales, animales y la cadena alimentaria.
Priscila Katherine León Orellana +2 more
core +1 more source
Enterobacterias aisladas de rizoplano y rizósfera y su potencial como promotoras de crecimiento de Asparagus officinalis L. [PDF]
, 2018 En el rizoplano y rizósfera de Asparagus officinalis L. “espárrago” se aislaron enterobacterias, con el objetivo de determinar su potencial como promotoras de crecimiento en plantas.
Segura Caro, Joan Joseph +1 more
core +1 more source
Identification of multidrug-resistant enterobacteriaceae in fecal samples from infants residing in Talara, Piura, Peru. [PDF]
Rev Peru Med Exp Salud Publica, 2022 Gonzales-Rodríguez AO +3 more
europepmc +1 more source
Molecular Oncology, EarlyView.Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou +4 more
wiley +1 more source
Molecular Oncology, EarlyView.Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley +1 more source
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
Revisión Sistemática de la resistencia antimicrobiana en Enterobacterias en aislamientos intrahospitalarios en Colombia [PDF]
, 2013 Introducción. La resistencia bacteriana es un problema de salud pública a nivel mundial que compromete seriamente la capacidad de tratar infecciones. Objetivos.
González Rojas, Leidy Esperanza
core