Results 141 to 150 of about 11,402 (288)
FEBS Open Bio, EarlyView.Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu +5 more
wiley +1 more source
FEBS Open Bio, EarlyView.We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies +3 more
wiley +1 more source
Memorias del Instituto de Investigaciones en Ciencias de la Salud, 2017 El objetivo de este estudio descriptivo, retrospectivo y transversal fue determinar la sensibilidad a los antimicrobianos de las enterobacterias obtenidas de los cultivos de orina en el Hospital Central del Instituto de Previsión Social (IPS) y comparar ...
Myriam Leguizamón +2 more
doaj
Detección de carbapenemasas en enterobacterias [PDF]
, 2016 76 p.Las bacterias Gram-negativo multirresistentes son un grave problema de salud en todo el mundo. Ello se relaciona con la gravedad de las infecciones que éstas pueden causar, así como también las dificultades para establecer un tratamiento empírico (e
Abaca Castillo, Elsa Paulina (Prof. Guía) +1 more
core +1 more source
FEBS Open Bio, EarlyView.dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon +6 more
wiley +1 more source
Integrons: gene collectors [PDF]
, 2010 Los integrones son estructuras genéticas que han despertado gran interés, debido a que algunos de ellos vehiculizan genes de resistencia a los antimicrobianos.
Di Conza, José Alejandro +1 more
core
Enzymatic degradation of biopolymers in amorphous and molten states: mechanisms and applications
FEBS Open Bio, EarlyView.This review explains how polymer morphology and thermal state shape enzymatic degradation pathways, comparing amorphous and molten biopolymer structures. By integrating structure–reactivity principles with insights from thermodynamics and enzyme engineering, it highlights mechanisms that enable efficient polymer breakdown.
Anđela Pustak, Aleksandra Maršavelski
wiley +1 more source
[Comparison two blood culture bottles for the recovery of Enterobacteriaceae]. [PDF]
Rev Esp Quimioter, 2021 De Malet A +3 more
europepmc +1 more source
The role of lipid metabolism in neuronal senescence
FEBS Open Bio, EarlyView.Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari +2 more
wiley +1 more source
[Prospective study of the incidence density of multi-resistant microorganisms and Clostridioides difficile during the period 2012- 2019 in the Canary Islands]. [PDF]
Rev Esp Quimioter, 2021 de Arriba-Fernández A +3 more
europepmc +1 more source