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Microbial regulation of enteroendocrine cells
Med, 2021There has been an enormous interest to investigate impact of gut microbiota on host physiology over the past decade. To further understand its role at organismal level, it is important to delineate host-microbiota interaction at tissue and cell level.
Arora, Tulika +3 more
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Enteroendocrine Cells: Chemosensors in the Intestinal Epithelium
Annual Review of Physiology, 2016The enteroendocrine system orchestrates how the body responds to the ingestion of foods, employing a diversity of hormones to fine-tune a wide range of physiological responses both within and outside the gut. Recent interest in gut hormones has surged with the realization that they modulate glucose tolerance and food intake through a variety of ...
Frank Reimann, Fiona Gribble
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The MicroRNA Repertoire in Enteroendocrine Cells: Identification of miR-375 as a Potential Regulator of the Enteroendocrine Lineage [PDF]
Endocrinology, 2015 Micro-RNAs (miRNAs) are crucial for many biological processes, but their role in the enteroendocrine development and differentiation has been neglected due to the elusive nature of the enteroendocrine cells. However, transgenic mice expressing fluorescent reporter proteins under the control of promoters for Cck, Gpr41, and Lgr5, ie, two different ...
Natalia Petersen +2 more
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Enteroendocrine cells in the Echinodermata
Cell and Tissue Research, 2019Enteroendocrine cells are endocrine-like cells found in the luminal epithelia of the digestive tract. These cells have been described in most animal phyla. In echinoderms, the cells have been described mainly in organisms of the class Asteroidea (sea stars) and Holothuroidea (sea cucumbers).
José E. García-Arrarás +2 more
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Enteroendocrine cells in gastrointestinal pathophysiology
Current Opinion in Pharmacology, 2013Enteroendocrine cells in the gastrointestinal tract play an important role in the regulation of appetite and digestive responses through the secretion of peptides. Their involvement in gastrointestinal diseases has been acknowledged, but relatively few studies have sought to clearly define their role in the pathogenesis or as therapeutic targets ...
Harrison, Elizabeth +2 more
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Enteroendocrine cells and lipid absorption
Current Opinion in Lipidology, 2011To examine recent papers linking enteroendocrine cells to lipid absorption.Specific inactivation of the proendocrine transcription factor neurogenin 3 (Ngn3) in the intestine leads to a loss of enteroendocrine cells, growth retardation, impaired lipid absorption and a high mortality during the weaning period.
Mellitzer, Georges, Gradwohl, Gerard
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Chemosensing in enteroendocrine cells: mechanisms and therapeutic opportunities
Current Opinion in Endocrinology, Diabetes & Obesity, 2021Purpose of review Enteroendocrine cells (EECs) are scattered chemosensory cells in the intestinal epithelium that release hormones with a wide range of actions on intestinal function, food intake and glucose homeostasis. The mechanisms by which gut hormones are secreted postprandially, or altered by antidiabetic agents and ...
Ming, Yang +2 more
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Enteroendocrine cell types revisited
Current Opinion in Pharmacology, 2013The GI-tract is profoundly involved in the control of metabolism through peptide hormones secreted from enteroendocrine cells scattered throughout the gut mucosa. A large number of recently generated transgenic reporter mice have allowed for direct characterization of biochemical and cell biological properties of these previously highly elusive ...
Engelstoft, Maja S +3 more
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Review: Enteroendocrine cells: Neglected players in gastrointestinal disorders? [PDF]
Therapeutic Advances in Gastroenterology, 2008 Enteroendocrine cells (EEC) form the basis of the largest endocrine system in the body. They secrete multiple regulatory molecules which control physiological and homeostatic functions, particularly postprandial secretion and motility. Their key purpose is to act as sensors of luminal contents, either in a classical endocrine fashion, or by a ...
John Mclaughlin +2 more
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