The influence of CpG and UpA dinucleotide frequencies on RNA virus replication and characterization of the innate cellular pathways underlying virus attenuation and enhanced replication [PDF]
Most RNA viruses infecting mammals and other vertebrates show profound suppression of CpG and UpA dinucleotide frequencies. To investigate this functionally, mutants of the picornavirus, echovirus 7 (E7), were constructed with altered CpG and UpA ...
Atkinson, Nicky J. +3 more
core +2 more sources
The infection mechanism of enterovirus 71
Identification of a specific viral receptor is important for understanding the virus infection mechanism. I identified P-selectin glycoprotein ligand-1 (PSGL-1) as one of the functional receptors for enterovirus 71 (EV71), a pathogen that causes hand, foot, and mouth disease.
openaire +3 more sources
Abstract Non‐immune hydrops fetalis (NIHF) can result from a multitude of underlying causes, such as fetal genetic diseases, congenital anomalies, infections, fetal arrhythmias, placental tumors, monochorionic twin complications, and other disorders.
Society for Maternal‐Fetal Medicine (SMFM) +3 more
wiley +1 more source
Sentinel Surveillance for Enterovirus 71, Taiwan, 1998
Outbreaks of enterovirus 71 have been reported around the world since 1969. The most recent outbreak occurred in Taiwan during April-July 1998. This hand, foot, and mouth disease epidemic was detected by a sentinel surveillance system in April at the ...
Trong-Neng Wu +7 more
doaj +1 more source
Molecular analysis of virulent determinants of enterovirus 71. [PDF]
Enterovirus 71 (EV71) is the most important causative agent of hand, foot and mouth disease (HFMD) in children. In most cases, it is a self-limiting illness.
Renqing Li +4 more
doaj +1 more source
A novel mechanism underlying the innate immune response induction upon viral-dependent replication of host cell mRNA: A mistake of +sRNA viruses' replicases [PDF]
Viruses are lifeless particles designed for setting virus-host interactome assuring a new generation of virions for dissemination. This interactome generates a pressure on host organisms evolving mechanisms to neutralize viral infection, which places the
Colombo, Maria Isabel +1 more
core +2 more sources
ABSTRACT Background Quantifying the burden of respiratory syncytial virus (RSV) in adults is challenging compared to influenza, and data among older adults remain scarce in Japan. Country‐specific evidence is essential to support RSV vaccination policy.
Haruka Maeda +24 more
wiley +1 more source
The cross-reactivity of the enterovirus 71 to human brain tissue and identification of the cross-reactivity related fragments [PDF]
Background EV71 occasionally cause a series of severe neurological symptoms, including aseptic meningitis, encephalitis, and poliomyelitis-like paralysis. However, the neurological destruction mechanism was remained to be clarified.
Chun Jia +10 more
core +1 more source
Curcuminoids amplify host innate antiviral immunity via the CRYAB‐RBM26 axis in viral infection
DMC/CUR antagonize viral hijacking of host nucleic acid resources and finely regulate the induction and effector phases of the type I interferon (IFN‐I) pathway through the CRYAB‐RBM26 axis. This molecular axis serves as a key downstream regulator for DMC/CUR activation of the IFN‐I pathway.
Tingting Chen +18 more
wiley +1 more source
Milrinone in Enterovirus 71 Brain Stem Encephalitis
Enterovirus 71 (EV71) was implicated in a widespread outbreak of hand-foot-and-mouth disease (HFMD) across the Asia Pacific area since 1997 and has also been reported sporadically in patients with brain stem encephalitis. Neurogenic shock with pulmonary
SHIH-MIN eWANG +2 more
doaj +1 more source

