Results 111 to 120 of about 32,839 (311)

Supporting Agile Development with Participative Enterprise Modeling

Agile Modeling (AM) provides a set of best practices of “light-weight” modeling to support the modeling process on a macro level within the agile development teams.
Stirna, Jānis, Kirikova, Mārīte
core  

Diffusion‐Based Generative Model With Scaffold‐Hopping Strategy Yields Highly Potent Bioactive Molecules

Advanced Science, EarlyView.
SMarT‐Diff introduces a multi‐objective generative paradigm that integrates scaffold hopping with structure‐aware scoring to enable controlled exploration beyond the training distribution. The framework consistently balances drug‐likeness, synthesizes accessibility and bioactivity, yielding chemically diverse candidates with enhanced properties.
Yuwei Yang, Xiaoqing Gong, Shukai Gu, Jing Li, Bo Liu, Yanan Tian, Qianqian Zhang, Xiaojun Yao, Huanxiang Liu   +8 more
wiley   +1 more source

Identifying HCI Patterns for the Support of Participatory Enterprise Modeling on Multi-touch Tables

, 2019
Part 3: Reference Architectures and PatternsInternational audienceThis paper deals with the question of how software enabling participatory enterprise modeling on a multi-touch table should be designed.
Kurt Sandkuhl, Gutschmidt, Anne,, Valentina Sauer, Kashevnik, Alexey, Anne Gutschmidt, Sauer, Valentina, Alexey Kashevnik, Sandkuhl, Kurt, Sandkuhl, Kurt,, Kashevnik, Alexey,, Sauer, Valentina,, Gutschmidt, Anne   +11 more
core   +1 more source

ZDHHC17‐Mediated CDK4 Palmitoylation Drives Cell Cycle Progression and Orchestrates Cancer Immune Surveillance

Advanced Science, EarlyView.
ZDHHC17 palmitoylates CDK4, which together with TRAF6‐mediated ubiquitination, drives cell cycle progression and immune surveillance, revealing a rational combination of CDK4 inhibitors with immune checkpoint blockers for ZDHHC17‐driven cancers. ABSTRACT Uncontrolled cell cycle progression is a hallmark of cancer, tightly regulated by both intrinsic ...
Zekang Wang, Peipei Song, Xueji Wu, Lei Wang, Wei Xie, Pinning Feng, Chao Cheng, Jianping Guo   +7 more
wiley   +1 more source

Evolution of an Enterprise Modeling Method – Next Generation Improvements of EKD

, 2012
Part 1: Enterprise ModelingInternational audienceThe field of Enterprise Modeling (EM) consists of many methods and method development is one of the key activity areas of EM practitioners and researchers. This paper ponders on future improvements for one
Persson, Anne,, Stirna, Janis, Persson, Anne, Stirna, Janis,, Janis Stirna, Anne Persson   +5 more
core   +1 more source

Integrated Opto–Biomechatronics For Single Muscle Fibre Structure‐Function Assessment: The MyoRobot 3.0

Advanced Science, EarlyView.
We present the MyoRobot 3.0, an advanced platform that combines high‐resolution imaging with automated mechanical testing to improve the accuracy of single muscle fibre analysis. The system tracks fibre diameter changes during stretch, preventing major stress miscalculations.
Michael Haug, Moritz Hellmann, Larysa Kovbasyuk, Maria Eleni Vazakidou, Milena Theis, Oliver Friedrich   +5 more
wiley   +1 more source

Holonic Business Process Modeling in Small to Medium Sized Enterprises

Asian Journal of Technology Management, 2012
Holonic modeling analysis which is the application of system thinking in design, manage, and improvement, is used in a novel context for business process modeling. An approach and techniques of holon and holarchies is presented specifically for small and
Nur Budi Mulyono, Tezar Yuliansyah Saputra, Nur Arief Rahmatsyah   +2 more
doaj   +2 more sources

Research of methods of modeling of mass service enterprise

Вестник Дагестанского государственного технического университета: Технические науки
Objective. The purpose of the study is to use artificial intelligence tools to optimize and model the automated organization of work at a mass service enterprise. Method.
Sh. M. Jafarova, S. M. Akhmedova, A. G. Aliyeva   +2 more
doaj   +1 more source

Lessons from Facilitating Participatory Enterprise Modeling (Keynote)

, 2018
Enterprise Modeling (EM) has become a widespread activity in enterprises. Strategy development, business process mapping, requirements engineering, product development, enterprise architecture management, information system design are just a few examples
Stirna, Janis
core  

Adaptation of enterprise modeling methods for large language models

Large language models (LLM) are considered by many researchers as promising technology for automating routine tasks. Results from applying LLM in engineering disciplines such as Enterprise Modeling also indicate potential for the support of modeling ...
Barn, Balbir S.,, Sandkuhl, Kurt,, Barat, Souvik,   +2 more
core   +1 more source