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Obesity, Low-Grade Chronic Inflammation, and Clinical Outcomes in Spondyloarthritis: A Translational Synthesis. [PDF]

Metabolites
Belančić A, Radić M, Rogoznica Pavlović M, Vučković M, Prižmić PŠ, Gkrinia EMM, Radić J, Fajkić A.   +7 more
europepmc   +1 more source

The Gut-Enthesis Axis and the Pathogenesis of Spondyloarthritis

Seminars in Immunology, 2021
Subclinical inflammation is associated with Spondylarthritis (SpA). SpA patients show features of dysbiosis, altered gut barrier function, and local expansion of innate and innate-like cells involved in type 3 immune response. The recirculation of intestinal primed immune cells into the bloodstream and, in some cases, in the joints and the inflamed ...
Akihiro Nakamura, Daniele Mauro, Francesco Ciccia   +2 more
exaly   +4 more sources

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The effect of mechanical stress on enthesis homeostasis in a rat Achilles enthesis organ culture model

Journal of Orthopaedic Research, 2021
AbstractTendons and ligaments are jointed to bones via an enthesis that is essential to the proper function of the muscular and skeletal structures. The aim of the study is to investigate the effect of mechanical stress on the enthesis. We used ex vivo models in organ cultures of rat Achilles tendons with calcaneus including the enthesis. The organ was
Taichi Saito, Ryo Nakamichi, Aki Yoshida, Takaaki Hiranaka, Yuki Okazaki, Satoshi Nezu, Minami Matsuhashi, Yasunori Shimamura, Takayuki Furumatsu, Keiichiro Nishida, Toshifumi Ozaki   +10 more
openaire   +2 more sources

Enthesis Repair – State of Play

Biomaterials Advances
The fibrocartilaginous enthesis is a highly specialised tissue interface that ensures a smooth mechanical transfer between tendon or ligament and bone through a fibrocartilage area. This tissue is prone to injury and often does not heal, even after surgical intervention.
Dimitrios Zeugolis
exaly   +3 more sources

ENTHESIS AS AN ORGAN AND ITS PATHOLOGIES

Journal of Ural Medical Academic Science, 2022
Excessive overstrain of the tendon apparatus occurs in athletes and people performing heavy physical work. Untimely treatment, or its complete absence, can lead to the development of severe diseases of the musculoskeletal system. The effectiveness of therapy is influenced by the doctor’s understanding of modern ideas about the pathogenesis of ...
Alexander A. Zhilyakov, Margarita L. Kokorina, Elena I. Zerchaninova   +2 more
openaire   +1 more source

The enthesis: a review of the tendon-to-bone insertion [PDF]

Muscle Ligaments and Tendons Journal, 2019
The integration of tendon into bone occurs at a specialized interface known as the enthesis. The fibrous tendon to bone enthesis is established through a structurally continuous gradient from uncalcified tendon to calcified bone. The enthesis exhibits gradients in tissue organization classified into four distinct zones with varying cellular ...
Apostolakos, John, Durant, Thomas J. S., Dwyer, Corey R., Russell, Ryan P., Weinreb, Jeffrey H., Alaee, Farhang, Beitzel, Knut, McCarthy, Mary Beth R., Cote, Mark P., Mazzocca, Augustus D.   +9 more
openaire   +2 more sources

Validity of enthesis ultrasound assessment in spondyloarthropathy

Annals of the Rheumatic Diseases, 2009
To develop an ultrasound enthesis score and to assess its validity in the diagnostic classification of the spondyloarthropathies (SpAs).Twenty-five patients with SpA and 29 healthy controls participated in a blinded, gender-matched, cross-sectional study involving ultrasound assessment. The following entheses were explored bilaterally: proximal plantar
E, de Miguel, T, Cobo, S, Muñoz-Fernández, E, Naredo, J, Usón, J C, Acebes, J L, Andréu, E, Martín-Mola   +7 more
openaire   +2 more sources