Results 251 to 260 of about 1,567,212 (302)

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

The growth of entire and random entire function

Matematychni Studii, 2008
openaire   +1 more source

Covariate adjustment in randomized clinical trials: From general theory to practical insights. [PDF]

Clin Trials
Bannick MS, Yi Y, Ye T.
europepmc   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Tightly Coupled GNSS/IMU Hybrid Navigation Using Factor Graph Optimization with NLOS Detection Capability. [PDF]

Sensors (Basel)
Tanimura H, Tsujii T.
europepmc   +1 more source

Three-dimensional visualization of nerves in bones of the human hand in osteoarthritis. [PDF]

JBMR Plus
Fuller-Jackson JP, Tee R, Thai J, Ek ET, Tham S, Ivanusic J.   +5 more
europepmc   +1 more source

Vector characteristics of the sound field based on a single vector hydrophone. [PDF]

PLoS One
Wang C, Jia S, Zhang Y, Zhang Q, Zhu R.
europepmc   +1 more source

Position-dependent feedback drives scaling and robustness of morphogen gradients. [PDF]

Proc Natl Acad Sci U S A
Mosby LS, Hadjivasiliou Z.
europepmc   +1 more source

Energy Measurement Characteristics of Electricity Meters with Different Input Configurations Under IEC 61000-4-19-Based Conducted Disturbances. [PDF]

Sensors (Basel)
Sadkowski G, Bień A.
europepmc   +1 more source