Results 131 to 140 of about 824,119 (290)

Function‐driven design of a surrogate interleukin‐2 receptor ligand

open access: yesFEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang   +9 more
wiley   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

open access: yesFEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira   +3 more
wiley   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

open access: yesFEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo   +2 more
wiley   +1 more source

Entire solutions of semilinear elliptic equations

open access: yesElectronic Journal of Differential Equations, 2004
Summary: We consider existence of entire solutions of a semilinear elliptic equation \(\Delta u= k(x) f(u)\) for \(x \in \mathbb R^n\), \(n\geq 3\). Conditions of the existence of entire solutions have been obtained by different authors. We prove a certain optimality of these results and new sufficient conditions for the nonexistence of entire ...
Alexander Gladkov, Nickolai Slepchenkov
openaire   +2 more sources

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

open access: yesFEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf   +6 more
wiley   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

open access: yesFEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Radial solutions of singular nonlinear biharmonic equations and applications to conformal geometry

open access: yesElectronic Journal of Differential Equations, 2003
Positive entire solutions of the singular biharmonic equation $Delta^2 u + u^{-q}=0$ in $mathbb{R}^n$ with $q>1$ and $ngeq 3$ are considered. We prove that there are infinitely many radial entire solutions with different growth rates close to quadratic ...
P. J. McKenna, Wolfgang Reichel
doaj  

Semi-Supervised Novelty Detection Using SVM Entire Solution Path

open access: green, 2013
Frank de Morsier   +4 more
openalex   +2 more sources

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