Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
A new proof for the existence of an equivariant entire solution connecting the minima of the potential for the system Δu - W_u (u) = 0 [PDF]
, 2011 Nicholas D. Alikakos
openalex +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Quasilinear problems with two parameters including superlinear and gradient terms
Electronic Journal of Differential Equations, 2014 In this article, we establish conditions for the existence of solutions for a quasilinear elliptic two-parameter problem with dependence on the gradient term in smooth bounded domains or in the whole space R^N.
Manuela C. Rezende, Carlos A. Santos
doaj
Pointwise gradient bounds for entire solutions of elliptic equations\n with non-standard growth conditions and general nonlinearities [PDF]
, 2019 Cecilia Cavaterra +4 more
openalex +1 more source
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
Growth of entire solutions of algebraic differential equations
Electronic Journal of Differential Equations, 2012 In this article, by means of the normal family theory, we estimate the growth order of entire solutions of some algebraic differential equations and extend the result by Qi et al [14]. We also give some examples to show that our results occur in some
Wenjun Yuan, Yezhou Li, Jianming Lin
doaj