Results 91 to 100 of about 26,431 (199)

Fast automated adjoints for spectral PDE solvers. [PDF]

Proc Natl Acad Sci U S A
Skene CS, Burns KJ.
europepmc   +1 more source

PDE4D and PDE3B orchestrate distinct cAMP microdomains in 3T3‐L1 adipocytes

British Journal of Pharmacology, EarlyView.
Basal conditions: •Ins/PDE3B lowers cytoplasmic cAMP (cyt‐cAMP) without affecting plasma membrane cAMP (pm‐cAMP). •Insulin decreases lipid droplet cAMP (LD‐cAMP) independent of PDE3B. •FGF1/PDE4D modestly reduces both cyt‐ and pm‐cAMP, while PDE4D alone can modulate LD‐cAMP. ISO stimulation: •Ins/PDE3B has minimal impact on cyt‐cAMP.
Johannes Krier, David Spähn, David Arturo Juarez Lopez, Judith L. Nono, Judith Seigner, Lisa Jacob, Siegfried Ussar, Robert Lukowski, Andreas L. Birkenfeld, Gencer Sancar   +9 more
wiley   +1 more source

Fast Numerical Solvers for Parameter Identification Problems in Mathematical Biology. [PDF]

J Sci Comput
Benková K, Pearson JW, Ptashnyk M.
europepmc   +1 more source

An intracellular recombinant single‐chain variable antibody fragment as a new class of phosphodiesterase type 5 inhibitors

British Journal of Pharmacology, EarlyView.
Background and Purpose Cyclic guanosine monophosphate (cGMP) is a ubiquitous second messenger involved in human (patho‐)physiology. Phosphodiesterase 5 (PDE5) is a major cGMP hydrolyzing enzyme in many cell types including vascular smooth muscle cells (VSMCs). Several highly selective PDE5 inhibitors are in clinical use. However, there are currently no
Kürsat Kirkgöz, Sophie Sprenger, Olga Schweigert, Sanika Mohagaonkar, Matti Walsdorff, Tanja Zeller, Filip Berisha, Viacheslav O. Nikolaev, Sergei D. Rybalkin   +8 more
wiley   +1 more source

Plant-derived exosomes: an emerging delivery platform for cancer therapy. [PDF]

J Nanobiotechnology
Zhou Y, Zhao X, Li M, Liu Y, Wu Y, Fan M, Cai S, Zheng W, Wang L.   +8 more
europepmc   +1 more source

Differential segment‐specific signalling pathways for guanylate cyclase C‐activated anion secretion in murine ileocolon

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Guanylate cyclase‐C (GC‐C) is the receptor for endogenous (uro)guanylin peptides, bacterial toxins and pharmacological analogues. Receptor activation leads to intestinal fluid loss, but also activates an antiproliferative pathway and is a promising target in colorectal cancer therapy.
Renjie Xiu, Johannes Reiner, Franz Hofmann, Azam Salari, Ursula Seidler   +4 more
wiley   +1 more source

NeuberNet: a neural operator solving elastic-plastic partial differential equations at V-notches from low-fidelity elastic simulations. [PDF]

Commun Eng
Grossi T, Beghini M, Benedetti M.
europepmc   +1 more source

Computing Skinning Weights via Convex Duality

Computer Graphics Forum, EarlyView.
We present an alternate optimization method to compute bounded biharmonic skinning weights. Our method relies on a dual formulation, which can be optimized with a nonnegative linear least squares setup. Abstract We study the problem of optimising for skinning weights through the lens of convex duality.
J. Solomon, O. Stein
wiley   +1 more source

Development of functional cheese sticks using konjac glucomannan: regulated pickering double emulsions under different heat treatments. [PDF]

Food Chem X
Xu W, Kang M, Zhang L, Yin Y, Luo D, Zhang X, Zhang L, Li L, Du S.   +8 more
europepmc   +1 more source

SDFs from Unoriented Point Clouds using Neural Variational Heat Distances

Computer Graphics Forum, EarlyView.
We propose a novel variational approach for computing neural Signed Distance Fields (SDF) from unoriented point clouds. We first compute a small time step of heat flow (middle) and then use its gradient directions to solve for a neural SDF (right). Abstract We propose a novel variational approach for computing neural Signed Distance Fields (SDF) from ...
Samuel Weidemaier, Florine Hartwig, Josua Sassen, Sergio Conti, Mirela Ben‐Chen, Martin Rumpf   +5 more
wiley   +1 more source