Results 121 to 130 of about 1,940 (229)

An intuitive method to calculate the utilization distribution of an animal from step‐selection analysis

open access: yesMethods in Ecology and Evolution, EarlyView.
Abstract Step‐selection analysis (SSA) is a popular tool for estimating resource/habitat selection conditional on the local availability of conditions as determined by an animal's movement capacity. These models can be subsequently used to parameterize a movement model; however, most SSAs focus instead merely on interpreting the direction and magnitude
Natasha Ellison‐Neary   +4 more
wiley   +1 more source

Physics-Informed Boundary Integral Networks (PIBI-Nets): A Data-Driven Approach for Solving Partial Differential Equations

open access: yes
Partial differential equations (PDEs) are widely used to describe relevant phenomena in dynamical systems. In real-world applications, we commonly need to combine formal PDE models with (potentially noisy) observations.
Roth, Volker, Nagy-Huber, Monika
core   +1 more source

Update on Non‐Biological and RNA‐Based Therapeutics in Chronic Inflammatory Diseases: Precision Medicine Through Small Molecules: An EAACI Position Paper

open access: yesAllergy, EarlyView.
ABSTRACT In the last decades, critical advancements in research technology and knowledge on disease mechanisms steered therapeutic approaches for chronic inflammatory diseases towards unprecedented target specificity. For allergic and chronic lung diseases, biologic drugs pioneered this goal, acquiring on the way—through the clinical use of monoclonal ...
F. Roth‐Walter   +20 more
wiley   +1 more source

Experiences with Physics-Informed Neural Networks for Optimal Control Problems

open access: yes
Neural networks can be used to parametrize solutions of partial differential equations (PDEs). Specifically, physics-informed neural networks (PINNs) have gained popularity since they do not require numerically simulated or experimental data for training.
Wagner, Johannes   +2 more
core   +1 more source

Compartmentalisation in cAMP signalling: A phase separation perspective

open access: yesBritish Journal of Pharmacology, EarlyView.
Cells rely on precise spatiotemporal control of signalling pathways to ensure functional specificity. The compartmentalisation of cyclic AMP (cAMP) and protein kinase A (PKA) signalling enables distinct cellular responses within a crowded cytoplasmic space.
Milda Folkmanaite, Manuela Zaccolo
wiley   +1 more source

Non‐canonical PKG1 regulation in cardiovascular health and disease

open access: yesBritish Journal of Pharmacology, EarlyView.
It is well established that the cyclic GMP‐dependent protein kinase I (PKG1) is canonically activated by cyclic guanosine monophosphate (cGMP), enabling its regulation of vascular tone, cardiac function and smooth muscle homeostasis. However, diverse non‐canonical stimuli of PKG1 have also been identified.
Jie Su, Joseph Robert Burgoyne
wiley   +1 more source

Uniqueness of quasimonochromatic breathers for the generalized Korteweg-de Vries and Zakharov-Kuznetsov models

open access: yes
Consider the generalized Korteweg-de Vries (gKdV) equations with power nonlinearities $q=2,3,4\ldots$ in dimension $N=1$, and the Zakharov-Kuznetsov (ZK) model with integer power nonlinearities $q$ in higher dimensions $N\geq 2$.
Muñoz, Claudio   +3 more
core  

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