Results 141 to 150 of about 72,560 (254)

Orchestrated molecular changes of proliferative, migratory‐fibrillar, synaptic, and postmigratory compartments align with precocious cortex‐type specification in the early human pallium

Journal of Anatomy, EarlyView.
Early human cortical development is organized by transient cellular compartments that define cortical types before mature layers form. Analysis of the human fetal pallium (7.5–15 PCW) shows distinct spatiotemporal trajectories for the archicortex, mesocortex, and neocortex, with delayed but accelerated differentiation in allocortical regions.
Janja Kopić, Fran Božić, Alisa Junaković Munjas, Željka Krsnik, Ivica Kostović   +4 more
wiley   +1 more source

Partial EC outputs by degraded cues are amplified in hippocampal CA3 circuits for retrieving stored patterns

PLoS ONE, 2023
Hippocampus is known to be important for episodic memories. Measuring of hippocampal neural ensembles is therefore important for observing hippocampal cognitive processes such as pattern completion. Previous studies on pattern completion had a limitation
Kisang Eom
doaj  

Acute silencing of hippocampal CA3 reveals a dominant role in place field responses. [PDF]

, 2019
Neurons in hippocampal output area CA1 are thought to exhibit redundancy across cortical and hippocampal inputs. Here we show instead that acute silencing of CA3 terminals drastically reduces place field responses for many CA1 neurons, while a smaller ...
Davoudi, Heydar, Foster, David J
core  

Lower cerebral blood flow but not cerebrovascular response in elastin haploinsufficient mice

Experimental Physiology, EarlyView.
Abstract Elastin insufficiency is associated with structural differences in the large elastic arteries and cerebral artery dysfunction. However, previous studies have not assessed potential sex differences in cerebrovascular function. We measured cerebral blood flow (CBF) using arterial spin labeling MRI at rest and in response to hypercapnia challenge
Abigail E. Cullen, Emily H. Reeve, Nick R. Winder, Grant D. Henson, Nayantara Arora, Thomas Leonhardt, Ainsley Hogan, Sahana Krishna Kumaran, Naly Setthavonsack, Victoria Krajbich, Art Riddle, Benjamin Zimmerman, Nabil J. Alkayed, Martin M. Pike, Randall L. Woltjer, Ashley E. Walker   +15 more
wiley   +1 more source

rTCT: Rodent Triangle Completion Task to Facilitate Reverse Translational Study of Path Integration

Hippocampus, Volume 36, Issue 3, May 2026.
ABSTRACT Path integration is navigation in the absence of environmental landmarks and is a primary cognitive mechanism underlying spatial memory. Path integration performance is primarily assessed in humans using the Triangle Completion Task (TCT). In humans, TCT has shown promise for the early diagnosis of Alzheimer's disease.
Stephen Duncan, Sulaiman Rehman, Vladislava Segen, Irene Choi, Sami Lawrence, Om Kalani, Lisette Gold, Lillian Goldman, Sophia Ramlo, Kylene Stickel, Dylan Layfield, Thomas Wolbers, Zoran Tiganj, Ehren L. Newman   +13 more
wiley   +1 more source

Temperature Dependence of Paramagnetic Species in the Human Brain Tissue: An X‐Band EPR Study

Magnetic Resonance in Medicine, Volume 95, Issue 5, Page 3031-3043, May 2026.
ABSTRACT Purpose Paramagnetic ions are distributed throughout the human brain. The increased accumulation of these metals, such as iron and copper, can induce cellular death and the development of neurological diseases. Electron Paramagnetic Resonance (EPR) is a spectroscopic technique capable of detecting these ions in a given biological sample ...
André Avanzine, José Henrique Monteiro de Azevedo, Martina Huber, Fábio Seiji Otsuka, Maria Concepción García Otaduy, Roberta Diehl Rodriguez, Carlos Ernesto Garrido Salmon   +6 more
wiley   +1 more source

CEST MRI Processing Pipeline in Pilot Study of Alzheimer's Disease Patients

Magnetic Resonance in Medicine, Volume 95, Issue 5, Page 2828-2839, May 2026.
ABSTRACT Purpose To develop a processing pipeline combining neuroimaging analysis tools with CEST postprocessing and utilize it in a pilot study probing differences between cognitively impaired (CI) Alzheimer's disease (AD) patients and cognitively normal (CN) individuals.
Alexander Asturias, Fang Frank Yu, Elizabeth M. Davenport, Brendan J. Kelley, Ivan E. Dimitrov, Jochen Keupp, Elena Vinogradov   +6 more
wiley   +1 more source

The Development of Temporal Memory for Complex Events

Developmental Science, Volume 29, Issue 3, May 2026.
ABSTRACT Remembering when past events occurred is a key component of episodic memory, yet its developmental trajectory remains only partially understood. This study examined how children aged 6 and 10, compared to young adults, recall the timing of events embedded in an 11‐min cartoon.
Matteo Frisoni, Tiziana Pedale, Michele Capurso, Valerio Santangelo, Carlo Sestieri   +4 more
wiley   +1 more source

Maternal Choline Supplementation in a Mouse Model of Down Syndrome and Alzheimer’s Disease Generates Unique Expression Profile Mosaics Within Three Hippocampal Excitatory Neuronal Populations

The FASEB Journal, Volume 40, Issue 7, 15 April 2026.
Maternal choline supplementation (MCS) is utilized in the Ts65Dn mouse model of Down syndrome (DS) and Alzheimer's disease (AD). At ~6 months of age, laser capture microdissection and single population RNA‐sequencing of three hippocampal neuron populations (CA1 and CA3 pyramidal neurons and dentate gyrus granule cells) were conducted.
Melissa J. Alldred, Kyrillos W. Ibrahim, Harshitha Pidikiti, Sang Han Lee, Adriana Heguy, Gabriela Chiosis, Elliott J. Mufson, Grace E. Stutzmann, Stephen D. Ginsberg   +8 more
wiley   +1 more source

Increased levels of GFAP and purinergic P2X7 receptor in Alzheimer’s disease brain are associated with Aβ, tau pathologies and synaptic loss

Alzheimer’s Research & Therapy
Astrogliosis plays an important role in Alzheimer’s disease(AD). We characterized glial fibrillary acidic protein(GFAP) and purinergic P2X7 receptor(P2X7R) alterations in AD and their associations with amyloid-β levels, tau pathology and synaptic density.
Cinzia A. Maschio, Oscar Moreno, Junlong Wang, Upasana Maheshwari, Annika Keller, Uwe Konietzko, Daniel Razansky, Agneta Nordberg, Axel Rominger, Christoph Hock, Jordi Llop, Roger M. Nitsch, Ruiqing Ni   +12 more
doaj   +1 more source