Results 41 to 50 of about 10,071,969 (331)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Real-time determination of home scenarios based on YOLOv8 object detection
上海师范大学学报. 自然科学版A region entrance detection method based on lidar and depth camera data was proposed， by which efficient recognition of region entrance was achieved through average distance detection， width evaluation and smoothness analysis.
WANG Ruiqing, AN Kang, ZHANG Hui
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Ecology and Evolution, 2021 Burrows provide burrowing animals with a place to hibernate, reproduce, and avoid predators and harsh weather conditions and thus have a vital impact on their survival.
Shu‐Lin Wang, Fu‐Jiang Hou
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Journal of Engineering and Sustainable Development, 2012 The developing laminar flow in the entrance and disturbed regions of concentric circular pipes has been studied numerically. Both main pipe and disturbed pipe are concentric and stationary.
Ahmed Ali Shaker
doaj
International Journal of Thermofluids, 2023 This study obtains the semi-analytical solutions and explores the thermal characteristics of a thermally developing flow in a parallel plate channel, partially filled with a porous medium at the core, while considering local thermal non-equilibrium ...
M. Farrukh Baig +3 more
doaj +1 more source
Electrothermal instabilities in the entrance region of an MHD generator [PDF]
, 1969 Electron temperature instabilities in entrance region of magnetohydrodynamic ...
Smith, J. M.
core
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source