Results 51 to 60 of about 866,198 (336)

Wedelolactone, a Novel TLR2 Agonist, Promotes Neutrophil Differentiation and Ameliorates Neutropenia: A Multi‐Omics Approach to Unravel the Mechanism

open access: yesAdvanced Science, EarlyView.
Wedelolactone (WED), a natural TLR2 agonist, promotes neutrophil differentiation and enhances bactericidal function, offering a potential therapeutic strategy for neutropenia. Using a multi‐omics approach, this study reveals that WED activates the TLR2/MEK/ERK pathway, upregulating key transcription factors (PU.1, CEBPβ) to drive neutrophil development.
Long Wang   +16 more
wiley   +1 more source

Small and medium enterprises as a factor of the competitiveness of the national economy

open access: yesУченые записки Российской академии предпринимательства, 2021
In the article current state and tendencies of small and medium entrepreneurship development in the Russian economy is considered. The main objective and subjective reasons causing setofproblems of functioning of the Russian small andmedium ...
V. S. Balabanov   +2 more
doaj  

Antiemesis Corticosteroids Potentiate Checkpoint Blockade Efficacy by Normalizing the Immune Microenvironment in Metastatic Murine Breast Cancer

open access: yesAdvanced Science, EarlyView.
Corticosteroids improve the efficacy of immune checkpoint blockade therapy in metastatic murine breast cancer. By normalizing the tumor immune microenvironment, corticosteroids reduce immunosuppressive signals, restore T‐cell function, and promote antitumor immune responses, resulting in enhanced tumor control.
John D. Martin   +19 more
wiley   +1 more source

Optimization of price policy of entrepreneurial structures for acceptance on its basis the effective management decisions

open access: yesУченые записки Российской академии предпринимательства, 2021
The formation and implementation of the pricing policy of business structures, including the strategy and tactics of pricing, using theoretical and methodological principles, taking into account the specifics of activity and the competitive environment ...
T. V. Voronchenko   +2 more
doaj  

IGF‐1 Deficiency Serves as an Integrated Biomarker Pathogenic Driver and Predictor in Poor Ovarian Response

open access: yesAdvanced Science, EarlyView.
IGF‐1 deficiency underlies poor ovarian response (POR), as reduced levels in follicular fluid and granulosa cells impair antral follicle formation and compromise reproductive outcomes. Including IGF‐1 as a biomarker significantly enhances the accuracy of models predicting both PORrisk and pregnancy success.
Zhu Hu   +9 more
wiley   +1 more source

An emergence perspective on entrepreneurship: processes, structure and methodology [PDF]

open access: yes, 2008
This paper explores entrepreneurship from the perspective of emergence, drawing on literature in complexity theory, social theory and entrepreneurship.
Fuller, Ted   +2 more
core  

Profiling of Integrin Isoforms on Lung‐Tropic Exosomes by Spectrally and Kinetically Multiplexed Single‐Molecule Imaging

open access: yesAdvanced Science, EarlyView.
A spectrally and kinetically multiplexed single‐molecule imaging method is developed, which achieved simultaneous imaging of 12 exosomal proteins at an unparalleled single‐copy resolution. It is found that co‐occurrence of α6 integrin and the pairing β counterpart on single exosomes is essential for lung targeting, providing valuable information for ...
Songlin Liu   +10 more
wiley   +1 more source

Modeling the development of knowledge absorptive capacity in startup accelerators with a interpretive structural approach [PDF]

open access: yesمدیریت راهبردی دانش سازمانی, 2023
The success of accelerators requires continuous growth and improvement of the capacity to absorb knowledge from internal and external organizational resources.
zeinab bahreini   +3 more
doaj  

Cu─O─Al Interfacial Engineering on Cu Nanowires for Durable CO2 Electroreduction Into Multi‐Carbon Products

open access: yesAdvanced Science, EarlyView.
A Cu nanowire/AlOx core‐shell catalyst is reported for CO2 electroreduction. Acting as a Lewis acid, the AlOx shell not only stabilizes Cu+ species at the Cu─O─Al interface but also creates an alkaline local microenvironment via *OH adsorption. This dual functionality stabilizes the catalyst structure while promoting the C─C coupling process, resulting
Xiaodong Liu   +7 more
wiley   +1 more source

Social Factors Influencing University Technology Transfer and Commercialization: A Review Study [PDF]

open access: yesRāhburdhā-yi Mudīriyyat dar Niẓām-i Salāmat
Objective: University technology transfer and commercialization are key pillars of the knowledge-based economy; however, their success is not limited to organizational and economic structures.
Mahdi Khayatan   +2 more
doaj  

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