Results 141 to 150 of about 1,285,086 (339)

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Preparation of Tunable Cu−Ag Nanostructures by Electrodeposition in a Deep Eutectic Solvent

ChemElectroChem
The green transition requires new, clean, inexpensive, and sustainable strategies to prepare controllable bimetallic and multimetallic nanostructures. Cu−Ag nanostructures, for example, are promising bimetallic catalysts for different electrocatalytic ...
Elena Plaza‐Mayoral, Kim N. Dalby, Hanne Falsig, Ib Chorkendorff, Paula Sebastián‐Pascual, María Escudero‐Escribano   +5 more
doaj   +1 more source

Smart Surface of Steering Wheel Based on Triboelectric Nanogenerator and Artificial Intelligence in Driving Monitoring System

Nanomaterials
Real-time driving monitoring systems can use self-powered sensors based on artificial intelligence (AI) and triboelectric nanogenerators (TENGs). Here, we created a TENG-based self-powered intelligent steering wheel that can detect hand gripping.
Fengguang Fan, Shiju E, Mengzhe Kang, Yuting Fan, Qing Song, Yu Xie, Yuankai Zhou, Jiaheng Nie, Xin Cui, Yan Zhang   +9 more
doaj   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

Dual coating layers to enhance oxidation resistance for refractory high-entropy alloys

Results in Materials
Refractory high-entropy alloys (RHEAs) possess excellent high-temperature mechanical properties, making them have the promising potential for applications at temperatures higher than Ni-base superalloys.
Shao-Wei Huang, Jin-Tai Luo, Zhang-Hong Chang, Ting-En Shen, Jui-Ting Liang, Wei-Lin Hsu, Che-Wei Tsai, Jien-Wei Yeh   +7 more
doaj   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Acute Effects of Various Movement Noise in Differential Learning of Rope Skipping on Brain and Heart Recovery Analyzed by Means of Multiscale Fuzzy Measure Entropy [PDF]

, 2022
Alexander John, Anna Barthel, Johanna Wind, Nikolas Rizzi, Wolfgang I. Schöllhorn   +4 more
openalex   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Self-powered sensing platform based on triboelectric nanogenerators towards intelligent mining industry

Nature Communications
Gold’s crucial role in economic and technological developments has driven the industry towards underground mining, with air quality concerns challenging workers’ safety.
Lindong Liu, Yurui Shang, Andy Berbille, Morten Willatzen, Yuan Wang, Xunjia Li, Longyi Li, Xiongxin Luo, Jianwu Chen, Bin Yang, Cuifeng Du, Zhong Lin Wang, Laipan Zhu   +12 more
doaj   +1 more source

Developing novel high-Si 12 % Cr reduced-activation ferritic/martensitic cladding alloys via the cluster-formula approach and CALPHAD method

Materials & Design
The corrosion-resistance in lead–bismuth eutectic (LBE) coolant at elevated temperatures of traditional reduced-activation ferritic/martensitic (RAFM) steels could not meet the requirements for the application of fuel claddings.
Sen Ge, Ben Niu, Zhenhua Wang, Qing Wang, Qianfu Pan, Chaohong Liu, Chuang Dong, Peter K. Liaw   +7 more
doaj   +1 more source