Results 241 to 250 of about 1,215,012 (347)

Understanding and measuring mechanical signals in the tumor stroma

open access: yesFEBS Open Bio, EarlyView.
This review discusses cancer‐associated fibroblast subtypes and their functions, particularly in relation to extracellular matrix production, as well as the development of 3D models to study tumor stroma mechanics in vitro. Several quantitative techniques to measure tissue mechanical properties are also described, to emphasize the diagnostic and ...
Fàtima de la Jara Ortiz   +3 more
wiley   +1 more source

Protein crystallization and structure determination at room temperature in the CrystalChip

open access: yesFEBS Open Bio, Volume 15, Issue 4, Page 532-541, April 2025.
This protocol describes the implementation of a simple and user‐friendly microfluidic device called CrystalChip that allows the production of crystals by the counter‐diffusion method and their in situ analysis by serial crystallography. As an illustration, it is applied to determine the 3D structure of three proteins from data collected at room ...
Petr Pachl   +9 more
wiley   +1 more source

NPC1 promotes the progression of hepatocellular carcinoma by mediating the accumulation of neutrophils into the tumor microenvironment

open access: yesFEBS Open Bio, Volume 15, Issue 4, Page 661-673, April 2025.
Compared to normal tissues, NPC1 expression is significantly elevated in hepatocellular carcinoma tissues. Our findings indicate that NPC1 plays a key role in regulating neutrophil recruitment within the tumor, which is a critical factor in the progression of hepatocellular carcinoma and is closely linked to poor patient outcomes.
Songhai Yang   +3 more
wiley   +1 more source

L-arabinose exerts probiotic functions by improving gut microbiota and metabolism in vivo and in vitro

open access: yesJournal of Functional Foods
Prior investigations have primarily focused on the impact of L-arabinose on gut microbiota, with limited exploration into the dual mechanisms of L-arabinose on microbiota and metabolism both in vivo and in vitro.
Shasha Xiang   +11 more
doaj  

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