Results 111 to 120 of about 68,867 (287)

Die Pfeile der geschichtlichen Zeit

Österreichische Zeitschrift für Geschichtswissenschaften, 2002
So far, the domains of thermodynamics, evolution and historiography have rarely found a common, coherent platform. Following a recent wave of literature on the parallelism between cosmic and evolutionary history, the present article follows two basic ...
Karl H. Müller
doaj   +1 more source

MET variants with activating N‐lobe mutations identified in hereditary papillary renal cell carcinomas still require ligand stimulation

Molecular Oncology, EarlyView.
MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin, Audrey Vinchent, Marie Fernandes, Isabelle Damour, Agathe Laratte, Rémi Tellier, Gabriella O. Estevam, Jean‐Pascal Meneboo, Céline Villenet, Clotilde Descarpentries, James S. Fraser, Martin Figeac, Alexis B. Cortot, Etienne Rouleau, David Tulasne   +14 more
wiley   +1 more source

Heat flow reversals without reversing the arrow of time: The role of internal quantum coherences and correlations

Physical Review Research, 2019
One of the stunning consequences of quantum correlations in thermodynamics is the reversal of the arrow of time, recently shown experimentally in Micadei et al. [Nat. Commun.
C. L. Latune, I. Sinayskiy, F. Petruccione   +2 more
doaj   +1 more source

Plasma lipidomic and metabolomic profiles in high‐grade glioma patients before and after 72‐h presurgery water‐only fasting

Molecular Oncology, EarlyView.
Presurgery 72‐h fasting in GB patients leads to adaptations of plasma lipids and polar metabolites. Fasting reduces lysophosphatidylcholines and increases free fatty acids, shifts triglycerides toward long‐chain TGs and increases branched‐chain amino acids, alpha aminobutyric acid, and uric acid.
Iris Divé, Lisa Hahnefeld, Katharina J. Wenger, Donat Kögel, Joachim Steinbach, Gerd Geisslinger, Michael W. Ronellenfitsch, Irmgard Tegeder   +7 more
wiley   +1 more source

The role of quantum measurement in stochastic thermodynamics

npj Quantum Information, 2017
Rebuilding quantum thermodynamics on quantum measurement Measuring a quantum system is an ultimately random operation. It induces a genuinely quantum time arrow, increasing the system’s entropy. But because it perturbs its state, quantum measurement also
Cyril Elouard, David A. Herrera-Martí, Maxime Clusel, Alexia Auffèves   +3 more
doaj   +1 more source

Exploration of heterogeneity and recurrence signatures in hepatocellular carcinoma

Molecular Oncology, EarlyView.
This study leveraged public datasets and integrative bioinformatic analysis to dissect malignant cell heterogeneity between relapsed and primary HCC, focusing on intercellular communication, differentiation status, metabolic activity, and transcriptomic profiles.
Wen‐Jing Wu, Jianchao Wang, Fuqing Chen, Xuefeng Wang, Bin Lan, Ruyi Fu, Hong Wen, Fangfang Chen, Wei Hong, Tian‐Yu Tang, Ying He, Gang Chen, Jianyin Zhou, Hai‐Long Piao, Di Chen, Shu‐Yong Lin   +15 more
wiley   +1 more source

Decoherence, Chaos, and the Second Law

, 1994
We investigate implications of decoherence for quantum systems which are classically chaotic. We show that, in open systems, the rate of von Neumann entropy production quickly reaches an asymptotic value which is: (i) independent of the system ...
A. O. Caldeira, B. L. Hu, B. L. Hu, B. V. Chirikov, E. Joos, F. Haake, G. J. Milburn, G. M. Zaslavsky, J. Ford, J. P. Paz, Juan Pablo Paz, M. B. Berry, M. Gell-Mann, M. Gutzwiller, R. Omne`s, T. Dittrich, T. Dittrich, W. G. Unruh, W. H. Zurek, W. H. Zurek, W. H. Zurek, W. H. Zurek, W. H. Zurek, W. H. Zurek, W. H. Zurek, Wojciech Hubert Zurek   +25 more
core   +2 more sources

Comparing self‐reported race and genetic ancestry for identifying potential differentially methylated sites in endometrial cancer: insights from African ancestry proportions using machine learning models

Molecular Oncology, EarlyView.
Integrating ancestry, differential methylation analysis, and machine learning, we identified robust epigenetic signature genes (ESGs) and Core‐ESGs in Black and White women with endometrial cancer. Core‐ESGs (namely APOBEC1 and PLEKHG5) methylation levels were significantly associated with survival, with tumors from high African ancestry (THA) showing ...
Huma Asif, J. Julie Kim
wiley   +1 more source

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

Molecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas   +20 more
wiley   +1 more source

Thermodynamics: The Unique Universal Science

Entropy, 2017
Thermodynamics is a physical branch of science that governs the thermal behavior of dynamical systems from those as simple as refrigerators to those as complex as our expanding universe.
Wassim M. Haddad
doaj   +1 more source