Dual native G‐quadruplex folding is associated with chromatin looping at the MYC locus
BG4‐detectable G‐quadruplex (G4) in HaCaT and NHEK keratinocytes identified folded and unfolded G4s enriched at promoters/TSSs and active enhancers, whereas unfolded G4s also overlapped weak/poised enhancers. At MYC–PVT1, 3C‐qPCR detected enhancer–promoter looping only when G4s were simultaneously folded at both regulatory elements under native ...
Dieila Giomo de Lima +7 more
wiley +1 more source
Thermal performance, entropy generation, and machine learning insights of Al₂O₃-TiO₂ hybrid nanofluids in turbulent flow. [PDF]
Kanti PK +6 more
europepmc +1 more source
Impact of Surface Roughness on Flow Physics and Entropy Generation in Jet Impingement Applications. [PDF]
Alenezi A +4 more
europepmc +1 more source
Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang +3 more
wiley +1 more source
Methods to Calculate Entropy Generation. [PDF]
Osara JA, Bryant MD.
europepmc +1 more source
Dynamics of radiative Williamson hybrid nanofluid with entropy generation: significance in solar aircraft. [PDF]
Hussain SM.
europepmc +1 more source
Validity of a Wearable Digital Insole for Assessing Gait ON and OFF in Parkinson's Disease
ABSTRACT Objective Gait impairment is a distinctive symptom of Parkinson's disease that negatively impact mobility. We assessed the validity of wearable digital insoles against a validated reference gait analysis system for measuring select gait characteristics in patients with Parkinson's disease. Methods A comparative analysis between digital insoles
Deborah A. Hall +16 more
wiley +1 more source
Analysis of Entropy Generation for Mass and Thermal Mixing Behaviors in Non-Newtonian Nano-Fluids of a Crossing Micromixer. [PDF]
Lakhdar A +5 more
europepmc +1 more source
Entropy generation in radiative magneto-hydrodynamic mixed convective flow of viscoelastic hybrid nanofluid over a spinning disk. [PDF]
Ibrahim W, Gamachu D.
europepmc +1 more source
ABSTRACT Background Emerging evidence suggests that low‐frequency neural oscillations are dynamically regulated by consciousness levels, with the recovery of low cortical activity potentially serving as a neurophysiological substrate for conscious emergence. Targeted enhancement of these low‐frequency rhythms in patients with disorders of consciousness
Chuan Xu +10 more
wiley +1 more source

